ArticleCellular microbiology2008
The unique architecture of Bunyamwera virus factories around the Golgi complex.
Article in Cellular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- Review
- Article
- The Bunyamwera orthobunyavirus Gc glycoprotein head and stalk drives an infectious virion assembly pathway specific for the insect host.PLoS pathogens · 2026Article
- Host ESCRT machinery orchestrates the assembly of tomato spotted wilt virus ribonucleoproteins.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Remodelling of P-bodies and the cytoskeleton byThe Journal of general virology · 2026Article
- A Systematic Evaluation of Protein Phase Separation Predictors across Diverse Protein Landscapes.Computational and structural biotechnology journal · 2026Article
- Review
- Ultrastructural Insight into Rift Valley Fever Virus Pathogenesis in Different Human Cell Types.International journal of molecular sciences · 2025Article
- Host cytoskeleton and membrane network remodeling in the regulation of viral replication.Biophysics reports · 2025Article
- NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts.Nature communications · 2025Article
- Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture.Nature communications · 2024Article
- Rab27a GTPase and its effector Myosin Va are host factors required for efficient Oropouche virus cell egress.PLoS pathogens · 2024Article
- Article
- The Adaptive Immune Response againstViruses · 2024Review
- Imaging Bunyavirus Infections by Transmission Electron Microscopy: Conventional Sample Preparation vs High-Pressure Freezing and Freeze-Substitution.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Viral replication organelles: the highly complex and programmed replication machinery.Frontiers in microbiology · 2024Review
- Infectious Bursal Disease Virus Assembly Causes Endoplasmic Reticulum Stress and Lipid Droplet Accumulation.Viruses · 2023Article
- Article
- Comparison of Immunogenicity Between a Candidate Live Attenuated Vaccine and an Inactivated Vaccine for Cache Valley Virus.Viral immunology · 2023Article
- Insights from the Infection Cycle of VSV-ΔG-Spike Virus.Viruses · 2022Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Viral factories are novel structures built by viruses in infected cells. During their construction organelles are recruited and build a large scaffold for viral replication and morphogenesis. We have studied how a bunyavirus uses the Golgi to build the factory. With the help of confocal and 3D ultrastructural imaging together with molecular mapping in situ and in vitro we have characterized a tubular structure that harbours the viral replication complexes in a globular domain. Numerous ribonucleoproteins were released from purified tubes disrupted in vitro. Actin and myosin I were identified by peptide mass fingerprinting in isolated tubes while actin and the viral NSm non-structural protein were detected in the tubes' internal proteinaceous scaffold by immunogold labelling. Studies with NSm deletion mutants and drugs affecting actin showed that both NSm and actin are key factors for tube and virus assembly in Golgi. Three-dimensional reconstructions based on oriented serial sections of infected cells showed that tubes anchor cell organelles to Golgi stacks and make contacts with intracellular viruses. We propose that this new structure, unique among enveloped viruses, assembles in association with the most stable component of Golgi stacks, the actin-containing matrix scaffold, connecting viral replication and morphogenesis inside viral factories.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.