ArticleEuropean journal of immunology2008
A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR.
Article in European journal of immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity.Communications biology · 2025Article
- Replacement of TCR Dβ With Immunoglobulin DFrontiers in immunology · 2020Article
- The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.The Journal of experimental medicine · 2013Article
- Partial versus productive immunoglobulin heavy locus rearrangements in chronic lymphocytic leukemia: implications for B-cell receptor stereotypy.Molecular medicine (Cambridge, Mass.) · 2012Article
- Ten experiments that would make a difference in understanding immune mechanisms.Cellular and molecular life sciences : CMLS · 2012Article
- On the logic of restrictive recognition of peptide by the T-cell antigen receptor.Immunologic research · 2011Article
- Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production.Critical reviews in immunology · 2010Review
- Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Regulation of repertoire development through genetic control of DH reading frame preference.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
The D gene segment expressed in both the TCR and the BCR has a challenging behavior that begs interpretation. It is incorporated in three reading frames in the rearranged transcription unit but is expressed in antigen-selected cells in a preferred frame. Why was it so important to waste 2/3 of newborn cells? The hypothesis is presented that the D region is framework playing a role in both the TCR and the BCR by determining whether a signal is transmitted to the cell upon interaction with a cognate ligand. This assumption operates in determining haplotype exclusion for the BCR and in regulating the signaling orientation for the TCR. Relevant data as well as a definitive experiment challenging the validity of this hypothesis, are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.