SynthesisAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2009
5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data.
Synthesis in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Pooled it
- The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis.Molecular psychiatry · 2013Pooled it
- A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.Translational psychiatry · 2012Pooled it
- Pooled it
- Antidepressant response and the serotonin transporter gene-linked polymorphic region.Biological psychiatry · 2010Pooled it
- BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Pooled it
- Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.The British journal of psychiatry : the journal of mental science · 2016Trial
- Anxiety and Depression Traits Are Moderated by a Sex-Dependent Genetic Interaction Between 5-HTTLPR and BDNF.Brain sciences · 2026Article
- Analysis of Serotonin Transporter GeneInternational journal of molecular sciences · 2025Article
- Predicting anxiety-related personality traits by means of serotonergic VNTR variants STin2 and 5-HTTLPR.Journal of mood and anxiety disorders · 2023Article
- The Correlation Between Temperament and Fitness for Work According to the Persian Medicine Viewpoints.Galen medical journal · 2023Article
- Personality traits and polymorphisms of genes coding neurotransmitter receptors or transporters: review of single gene and genome-wide association studies.Annals of general psychiatry · 2021Review
- Personality, subjective well-being, and the serotonin 1a receptor gene in common marmosets (Callithrix jacchus).PloS one · 2021Article
- TheFrontiers in genetics · 2021Article
- Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity-Comparison with other anxiety-related temperamental dimensions.Molecular genetics & genomic medicine · 2020Article
- Toward an animal model of borderline personality disorder.Psychopharmacology · 2019Review
- Positive and balancing selection onEvolution letters · 2018Article
- INFLUENCE OF THE SEROTONERGIC SYSTEM POLYMORPHISM ON THE EXPRESSION OF DENTAL ANXIETY.Acta clinica Croatica · 2018Article
- The genetics of human personality.Genes, brain, and behavior · 2018Review
- Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females.The international journal of neuropsychopharmacology · 2017Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
We investigated the strength of evidence for association of the 5-HTTLPR polymorphism and the personality trait of Harm Avoidance. We used new primary data from a large sample of adults drawn from the Finnish population. We also applied meta-analytic techniques to synthesize existing published data. The large number of studies of the 5-HTTLPR polymorphism allowed us to apply a formal test of publication bias, as well as formally investigate the impact of potential moderating factors such as measurement instrument. Univariate ANOVA of primary data (n = 3,872), with 5-HTTLPR genotype as a between-groups factor, indicated no evidence of association with Harm Avoidance (P = 0.99). Meta-analysis indicated no evidence of significant association of 5-HTTLPR with Harm Avoidance (d = 0.02, P = 0.37), or EPQ Neuroticism (d = 0.01, P = 0.71), although there was evidence of association with NEO Neuroticism (d = 0.18, P < 0.001). Our analyses indicate that the 5-HTTLPR variant is not associated with Harm Avoidance. Together with our previous analyses of a large sample of participants with extreme Neuroticism scores (defined by the EPQ), we have data that excludes a meaningful genetic effect of the 5-HTTLPR on two measures of anxiety-related personality traits. There remains the possibility that the variant influences the NEO personality questionnaire measure of Neuroticism. However, a large, well-powered primary study is required to test this hypothesis directly and adequately.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.