ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Inadequate responders to osteoporosis treatment: proposal for an operational definition.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- The risk of subsequent osteoporotic fractures is decreased in subjects experiencing fracture while on denosumab: results from the FREEDOM and FREEDOM Extension studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Trial
- Treatment failure in osteoporosis: who will experience a new Fracture? TAILOR a retrospective study.Aging clinical and experimental research · 2025Article
- Pharmacogenetics of Response to Bisphosphonate Treatment in Postmenopausal Osteoporosis: A Prospective Study.Journal of bone metabolism · 2025Article
- Article
- Bone mineral density response prediction following osteoporosis treatment using machine learning to aid personalized therapy.Scientific reports · 2021Article
- Interactions of the microbiome with pharmacological and non-pharmacological approaches for the management of ageing-related musculoskeletal diseases.Therapeutic advances in musculoskeletal disease · 2021Review
- Treatment of osteoporosis with recombinant parathyroid hormone, utilisation of total body DXA to observe treatment effects on total body composition and factors determining response to therapy.Irish journal of medical science · 2019Article
- Thai Osteoporosis Foundation (TOPF) position statements on management of osteoporosis.Osteoporosis and sarcopenia · 2016Review
- Improving persistence and adherence to osteoporosis treatment: a challenge to solve.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Factors associated with bisphosphonate treatment failure in postmenopausal women with primary osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Observational
- Risk factors for treatment failure with antiosteoporosis medication: the global longitudinal study of osteoporosis in women (GLOW).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Observational
- Vitamin D and bone disease.BioMed research international · 2013Review
- Bone quality: from bench to bedside: opening editorial comment.Clinical orthopaedics and related research · 2011Article
- [Osteoporosis treatment with biphosphonates: Approaches to care reality].Atencion primaria · 2011Article
- Assessing response to osteoporosis therapy.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Article
- The effect of vitamin D and bisphosphonate on fracture healing: An experimental study.Journal of clinical orthopaedics and traumaArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe concept of inadequate response to osteoporosis treatment is not clear. In the literature several criteria have been used. We propose an operational definition of an inadequate responder based on the changes observed in bone mineral density and incident fractures while on therapy.
introductionFractures may occur in compliant patients even while on active treatment. These cases have been defined as inadequate responders (IR).
methodsWe reviewed the basis for this concept and propose an operational definition for IR.
resultsGood compliance and adequate calcium and vitamin D supplementation are the first requirement. The second requirement is a treatment period of at least 1 year, since before that time treatment may not have been fully effective. Fractures are the gold standard for measuring efficacy and changes in bone density and turnover markers may be surrogates. We propose classifying patient response as: Inadequate--incident fracture and a decrease in BMD greater than a significant change (Trend Assessment Margin or TAM); Possibly inadequate--incident fracture or a decrease in BMD greater than a significant change (TAM); and Appropriate--no fracture and no decrease in BMD greater than a significant change (TAM). Additional criteria (biochemical markers, bone quality parameters) may be taken into account.
conclusionA wide consensus on the IR concept is required given its clinical, regulatory, and reimbursement implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.