ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2008
The concept of heavy tamponades-chances and limitations.
Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Effect of shorter silicone oil tamponade time on visual function recovery and associated factors in patients with rhegmatogenous retinal detachment.BMC ophthalmology · 2026Trial
- Mechanisms of Retinal Displacement After PFCL-Assisted Rhegmatogenous Retinal Detachment Repair: Insights From a Computational Model.Investigative ophthalmology & visual science · 2026Article
- Physics-informed, phenotype-based endotamponade selection in vitreoretinal surgery: current agents and emerging vitreous substitutes.International journal of retina and vitreous · 2026Review
- Replacing the vitreous body with hydrogels: Rationale and strategies.Progress in retinal and eye research · 2025Review
- Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis.Investigative ophthalmology & visual science · 2025Article
- Risk Factors and Management of Intraocular Pressure Elevation After Vitrectomy Combined with Silicone Oil Tamponade.International journal of general medicine · 2024Review
- Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery.International journal of molecular sciences · 2023Review
- Physicochemical Properties of Explanted Silicone Oil After Use as an Intraocular Tamponade.Translational vision science & technology · 2022Article
- Retinal displacement following pars plana vitrectomy with silicone oil tamponade for rhegmatogenous retinal detachment.International ophthalmology · 2021Article
- Results of different strategies to manage complicated retinal re-detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Intraocular pressure changes during and after silicone oil endotamponade (Review).Experimental and therapeutic medicine · 2020Review
- Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review.Vision (Basel, Switzerland) · 2020Review
- Double Retinal Tamponade for Treatment of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy and Inferior Breaks.Journal of ophthalmology · 2020Article
- [Heavy liquids as intraoperative instrument in retinal surgery].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- A cross-linked hyaluronic acid hydrogel (Healaflow(®)) as a novel vitreous substitute.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- A new model for in vitro testing of vitreous substitute candidates.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Some physicochemical remarks on spontaneous emulsification of vitreal tamponades.BioMed research international · 2014Review
- Heavy silicone oil and intraocular inflammation.BioMed research international · 2014Review
- Tamponade or filling effect: changes of forces in myopic eyes.BioMed research international · 2014Review
- Silicone oil: different physical proprieties and clinical applications.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProliferative vitreoretinopathy in the inferior retina remains clinically challenging. Heavier than water intraocular tamponades have been developed to improve inferior tamponading properties. In addition to inferior PVR, there seem to be other applications such as persistent macular holes or PVR in trauma eyes. MATERIALS AND
methodsReview of the literature on clinical application of heavy tamponades. The review also discusses the theoretical background of heavy tamponades and possible future developments.
resultsThe parameters of an optimal intraocular tamponade are defined, and the influences of the specific gravity, buoyancy, interfacial tension, and viscosity are discussed. Perfluorocarbon liquids and partially fluorinated alkanes were associated with tamponade emulsification, intraocular inflammation, and rise in intraocular pressure that was less prominent in admixtures of these substances with silicone oil (heavy silicone oils). Two recently developed heavy silicone oil tamponades, Oxane HD and Densiron 68, are well-tolerated and have entered clinical practice. The side effects are associated with the chemical properties of the tamponading agent, and seem comparable to the ones seen with conventional silicone oil.
conclusionHeavy silicone oil tamponade improves inferior tamponade, and may be considered a new generation of intraocular tamponades.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.