ArticlePloS one2008
Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
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- The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease.International journal of molecular sciences · 2022Review
- Metabolic regulation of aging and age-related disease.Ageing research reviews · 2020Review
- The expression of select genes necessary for membrane-associated estrogen receptor signaling differ by sex in adult rat hippocampus.Steroids · 2019Article
- Article
- DNA methylation and cognitive aging.Oncotarget · 2015Review
- Diet-induced obesity attenuates endotoxin-induced cognitive deficits.Physiology & behavior · 2015Article
- Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway.Frontiers in cellular neuroscience · 2015Article
- Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats.International journal of biological sciences · 2015Article
- Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Superior pattern processing is the essence of the evolved human brain.Frontiers in neuroscience · 2014Review
- Dietary restriction in cerebral bioenergetics and redox state.Redox biology · 2014Review
- VennPlex--a novel Venn diagram program for comparing and visualizing datasets with differentially regulated datapoints.PloS one · 2013Article
- The effects of the ketogenic diet on behavior and cognition.Epilepsy research · 2012Review
- Metabolic context regulates distinct hypothalamic transcriptional responses to antiaging interventions.International journal of endocrinology · 2012Article
- GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats.PloS one · 2012Article
- Central role of the EGF receptor in neurometabolic aging.International journal of endocrinology · 2012Article
- Pancreas++: automated quantification of pancreatic islet cells in microscopy images.Frontiers in physiology · 2012Article
- Central leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain.Reviews in endocrine & metabolic disorders · 2011Review
- Impaired adaptive cellular responses to oxidative stress and the pathogenesis of Alzheimer's disease.Antioxidants & redox signaling · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
The level of dietary energy intake influences metabolism, reproductive function, the development of age-related diseases, and even cognitive behavior. Because males and females typically play different roles in the acquisition and allocation of energy resources, we reasoned that dietary energy intake might differentially affect the brains of males and females at the molecular level. To test this hypothesis, we performed a gene array analysis of the hippocampus in male and female rats that had been maintained for 6 months on either ad libitum (control), 20% caloric restriction (CR), 40% CR, intermittent fasting (IF) or high fat/high glucose (HFG) diets. These diets resulted in expected changes in body weight, and circulating levels of glucose, insulin and leptin. However, the CR diets significantly increased the size of the hippocampus of females, but not males. Multiple genes were regulated coherently in response to energy restriction diets in females, but not in males. Functional physiological pathway analyses showed that the 20% CR diet down-regulated genes involved in glycolysis and mitochondrial ATP production in males, whereas these metabolic pathways were up-regulated in females. The 40% CR diet up-regulated genes involved in glycolysis, protein deacetylation, PGC-1alpha and mTor pathways in both sexes. IF down-regulated many genes in males including those involved in protein degradation and apoptosis, but up-regulated many genes in females including those involved in cellular energy metabolism, cell cycle regulation and protein deacetylation. Genes involved in energy metabolism, oxidative stress responses and cell death were affected by the HFG diet in both males and females. The gender-specific molecular genetic responses of hippocampal cells to variations in dietary energy intake identified in this study may mediate differential behavioral responses of males and females to differences in energy availability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.