ArticlePloS one2008
Virus adaptation by manipulation of host's gene expression.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Effects of immune challenge on expression of life-history and immune trait expression in sexually reproducing metazoans-a meta-analysis.BMC biology · 2020Pooled it
- A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens.PloS one · 2012Pooled it
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- Screening and biochemical profiling of 'Mac-07' crosses for resistance to CLCuD under field and glasshouse conditions.BMC plant biology · 2025Article
- Protein embeddings reveal a continuous molecular landscape of host adaptation in waterfowl parvoviruses.Frontiers in bioinformatics · 2025Article
- The importance of epistasis in the evolution of viral pathogens.Virus evolution · 2025Review
- Transcriptomic insights into the epigenetic modulation of turnip mosaic virus evolution in Arabidopsis thaliana.BMC genomics · 2024Article
- Genetic basis ofeLife · 2024Article
- Adaptation of turnip mosaic virus toVirus evolution · 2024Article
- The evolving epidemiology of monkeypox virus.Cytokine & growth factor reviews · 2022Review
- Defects in plant immunity modulate the rates and patterns of RNA virus evolution.Virus evolution · 2022Article
- What is life?Molecular biology reports · 2021Article
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- When a knockout is an Achilles' heel: Resistance to one potyvirus species triggers hypersusceptibility to another one in Arabidopsis thaliana.Molecular plant pathology · 2021Article
- Plant virus evolution under strong drought conditions results in a transition from parasitism to mutualism.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Oxylipin Signaling Pathway Is Required for Increased Aphid Attraction and Retention on Virus-Infected Plants.Journal of chemical ecology · 2020Article
- In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV-2 genomic data.The Pan African medical journal · 2020Article
- Detection of Plant Viruses and Disease Management: Relevance of Genetic Diversity and Evolution.Frontiers in plant science · 2020Review
- Article
- The effects of a bacterial challenge on reproductive success of fruit flies evolved under low or high sexual selection.Ecology and evolution · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses adapt to their hosts by evading defense mechanisms and taking over cellular metabolism for their own benefit. Alterations in cell metabolism as well as side-effects of antiviral responses contribute to symptoms development and virulence. Sometimes, a virus may spill over from its usual host species into a novel one, where usually will fail to successfully infect and further transmit to new host. However, in some cases, the virus transmits and persists after fixing beneficial mutations that allow for a better exploitation of the new host. This situation would represent a case for a new emerging virus. Here we report results from an evolution experiment in which a plant virus was allowed to infect and evolve on a naïve host. After 17 serial passages, the viral genome has accumulated only five changes, three of which were non-synonymous. An amino acid substitution in the viral VPg protein was responsible for the appearance of symptoms, whereas one substitution in the viral P3 protein the epistatically contributed to exacerbate severity. DNA microarray analyses show that the evolved and ancestral viruses affect the global patterns of host gene expression in radically different ways. A major difference is that genes involved in stress and pathogen response are not activated upon infection with the evolved virus, suggesting that selection has favored viral strategies to escape from host defenses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.