ArticlePloS one2008
A polyadenylation factor subunit implicated in regulating oxidative signaling in Arabidopsis thaliana.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 103 citations in OpenAlex.
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- FLL2 modulatesiScience · 2025Article
- Insights into the role of N6-methyladenosine (m6A) in plant-virus interactions.Journal of virology · 2025Review
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- Characterizing the impact of CPSF30 gene disruption on TuMV infection inGM crops & food · 2024Article
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- The emerging role of epitranscriptome in shaping stress responses in plants.Plant cell reports · 2023Review
- Stress responses of plants through transcriptome plasticity by mRNA alternative polyadenylation.Molecular horticulture · 2023Review
- Alternative Polyadenylation Is a Novel Strategy for the Regulation of Gene Expression in Response to Stresses in Plants.International journal of molecular sciences · 2023Review
- Signatures of mRNA Alternative Polyadenylation inFrontiers in genetics · 2022Article
- Divergence in the Regulation of the Salt Tolerant Response BetweenFrontiers in plant science · 2022Article
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- HDA6-dependent histone deacetylation regulates mRNA polyadenylation inGenome research · 2020Article
- Genome-wide identification and expression analysis of YTH domain-containing RNA-binding protein family in common wheat.BMC plant biology · 2020Article
- A novel seed plants gene regulates oxidative stress tolerance in Arabidopsis thaliana.Cellular and molecular life sciences : CMLS · 2020Article
- A Biostimulant Obtained from the SeaweedInternational journal of molecular sciences · 2020Article
- Occurrence and Functions of mPlant physiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlants respond to many unfavorable environmental conditions via signaling mediated by altered levels of various reactive oxygen species (ROS). To gain additional insight into oxidative signaling responses, Arabidopsis mutants that exhibited tolerance to oxidative stress were isolated. We describe herein the isolation and characterization of one such mutant, oxt6. METHODOLOGY/PRINCIPAL
findingsThe oxt6 mutation is due to the disruption of a complex gene (At1g30460) that encodes the Arabidopsis ortholog of the 30-kD subunit of the cleavage and polyadenylation specificity factor (CPSF30) as well as a larger, related 65-kD protein. Expression of mRNAs encoding Arabidopsis CPSF30 alone was able to restore wild-type growth and stress susceptibility to the oxt6 mutant. Transcriptional profiling and single gene expression studies show elevated constitutive expression of a subset of genes that encode proteins containing thioredoxin- and glutaredoxin-related domains in the oxt6 mutant, suggesting that stress can be ameliorated by these gene classes. Bulk poly(A) tail length was not seemingly affected in the oxt6 mutant, but poly(A) site selection was different, indicating a subtle effect on polyadenylation in the mutant. CONCLUSIONS/SIGNIFICANCE: These results implicate the Arabidopsis CPSF30 protein in the posttranscriptional control of the responses of plants to stress, and in particular to the expression of a set of genes that suffices to confer tolerance to oxidative stress.
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