Evidence map›Paper›PMID 18545247›Full record

ReviewBone marrow transplantation2008

Prevention and treatment of acute GvHD.

C Messina, M Faraci, V de Fazio, G Dini, M P Calò, E Calore, EBMT Paediatric Working Party

Abstract readReview
PubMed Publisher
In one paragraph

Review in Bone marrow transplantation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Administration of FK506 from Late Stage of Disease Prolongs Survival of Human Prion-Inoculated Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Article
  4. Review
  5. Review
  6. Pain Management for Children during Bone Marrow and Stem Cell Transplantation.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2015
    Article
  7. Graft versus host disease: New insights into A2A receptor agonist therapy.Computational and structural biotechnology journal · 2015
    Review
  8. Article
  9. Article
  10. Clinical applications of mesenchymal stem cells.Journal of hematology & oncology · 2012
    Review
  11. Article
  12. Article
  13. Article
  14. Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccination.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2011
    Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

C MessinaBone Marrow Unit, Paediatric Onco-Haematology Clinic, University of Padova, Padova, Italy. chiara.messina@unipd.it
M Faraci
V de Fazio
G Dini
M P Calò
E Calore
EBMT Paediatric Working Party
Children's Research Hospital · JPUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GvHD remains a source of significant morbidity and mortality in the setting of allogeneic haematopoietic SCT. Improving outcomes in stem cell transplant recipients requires additional therapeutic modalities for GvHD, especially for patients who fail to respond to initial therapy with steroids. Moreover, while the absence of acute GvHD (aGvHD) is associated with a higher risk of relapse of the underlying malignant disease, severe aGvHD usually induces the occurrence of life-threatening complications such as severe infections. This article summarizes the current state of aGvHD prophylaxis and treatment.

Indexed as

ChildGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunosuppressive AgentsSteroidsTacrolimusT-Lymphocytes, RegulatoryTransplantation, HomologousTumor Necrosis Factor-alphaImmunosuppressive AgentsSteroidsTacrolimusTumor Necrosis Factor-alpha

Identifiers

PMID18545247
OpenAlexW2075110948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.