ArticleBMC biology2008
A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranes.
Article in BMC biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed, 412 citations in OpenAlex.
- Cork oak aquaporins: functional diversity and regulation with insights into drought response.Plant cell reports · 2026Article
- Phosphate Transporters Mediate the Uptake of Monothioarsenate.Plant, cell & environment · 2026Article
- A Semi-Quantitative Yeast Complementation Platform for Characterizing Urea and Ammonia Transport by Membrane Channels.Current protocols · 2026Article
- The evolution of the aquaporin gene family and drought tolerance mechanisms in green plants.Horticulture research · 2025Article
- Molecular characterization of Tetragonia tetragonoides (Pall.) Aquaporin (AQP) members and their roles in the response to combined high salinity-alkalinity-drought and heat stress.BMC plant biology · 2025Article
- Unraveling the role of OsPIP1;3 in arsenic transport in rice (Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Yeast Complementation Assays Demonstrating the Importance of the Affinity Tag Position in Membrane Protein Purification, as Exemplified bySmall science · 2025Article
- Integration of physio-biochemical, biological and molecular approaches to improve heavy metal tolerance in plants.3 Biotech · 2025Review
- Arsenic stress triggers active exudation of arsenic-phytochelatin complexes from Lupinus albus roots.Journal of experimental botany · 2024Article
- Tissue-specific deposition, speciation and transport of antimony in rice.Plant physiology · 2024Article
- Nutrient and mycoremediation of a global menace 'arsenic': exploring the prospects of phosphorus and Serendipita indica-based mitigation strategies in rice and other crops.Plant cell reports · 2024Review
- Arsenic (As) accumulation in different genotypes of indica rice (Oryza sativa L.) and health risk assessment based on inorganic As.Environmental monitoring and assessment · 2024Article
- Article
- Effects of Transporter Inhibitors and Chemical Analogs on the Uptake of Antimonite and Antimonate byToxics · 2023Article
- Do Antimonite and Silicon Share the Same Root Uptake Pathway by Lsi1 inPlants (Basel, Switzerland) · 2023Article
- Plasma membrane-associated calcium signaling regulates arsenate tolerance in Arabidopsis.Plant physiology · 2023Article
- Comprehensive Study of Si-Based Compounds in Selected Plants (Molecules (Basel, Switzerland) · 2023Review
- Negative Impacts of Arsenic on Plants and Mitigation Strategies.Plants (Basel, Switzerland) · 2023Review
- Classification and Gene Structure of Aquaporins.Advances in experimental medicine and biology · 2023Article
- A high-throughput yeast approach to characterize aquaporin permeabilities: Profiling the Arabidopsis PIP aquaporin sub-family.Frontiers in plant science · 2023Article
52 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArsenic is a toxic and highly abundant metalloid that endangers human health through drinking water and the food chain. The most common forms of arsenic in the environment are arsenate (As(V)) and arsenite (As(III)). As(V) is a non-functional phosphate analog that enters the food chain via plant phosphate transporters. Inside cells, As(V) becomes reduced to As(III) for subsequent extrusion or compartmentation. Although much is known about As(III) transport and handling in microbes and mammals, the transport systems for As(III) have not yet been characterized in plants.
resultsHere we show that the Nodulin26-like Intrinsic Proteins (NIPs) AtNIP5;1 and AtNIP6;1 from Arabidopsis thaliana, OsNIP2;1 and OsNIP3;2 from Oryza sativa, and LjNIP5;1 and LjNIP6;1 from Lotus japonicus are bi-directional As(III) channels. Expression of these NIPs sensitized yeast cells to As(III) and antimonite (Sb(III)), and direct transport assays confirmed their ability to facilitate As(III) transport across cell membranes. On medium containing As(V), expression of the same NIPs improved yeast growth, probably due to increased As(III) efflux. Our data furthermore provide evidence that NIPs can discriminate between highly similar substrates and that they may have differential preferences in the direction of transport. A subgroup of As(III) permeable channels that group together in a phylogenetic tree required N-terminal truncation for functional expression in yeast.
conclusionThis is the first molecular identification of plant As(III) transport systems and we propose that metalloid transport through NIPs is a conserved and ancient feature. Our observations are potentially of great importance for improved remediation and tolerance of plants, and may provide a key to the development of low arsenic crops for food production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.