ArticleJournal of periodontal research2008
Invasive differences among Porphyromonas gingivalis strains from healthy and diseased periodontal sites.
Article in Journal of periodontal research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Local and Systemic Effects ofMicroorganisms · 2023Review
- Genes Contributing toFrontiers in cellular and infection microbiology · 2017Article
- Genome Sequence of Porphyromonas gingivalis Strain AJW4.Genome announcements · 2015Article
- Invasion of Porphyromonas gingivalis strains into vascular cells and tissue.Journal of oral microbiology · 2015Article
- Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.PloS one · 2014Article
- Lessons learned and unlearned in periodontal microbiology.Periodontology 2000 · 2013Review
- The nucleoid-associated protein HUβ affects global gene expression in Porphyromonas gingivalis.Microbiology (Reading, England) · 2013Article
- The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells.Infection and immunity · 2011Article
- Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis.Immunity & ageing : I & A · 2010Article
- Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats.Infection and immunity · 2010Article
- NOD1 and NOD2 mediate sensing of periodontal pathogens.Journal of dental research · 2010Article
- Bacterial invasion of epithelial cells and spreading in periodontal tissue.Periodontology 2000 · 2010Review
- Differential virulence and innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis.Oral microbiology and immunology · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND AND
objectiveThe purpose of this study was to determine any difference between Porphyromonas gingivalis isolates from periodontally healthy sites as compared to those from diseased sites with respect to the ability to invade host cells. MATERIAL AND
methodsSubgingival plaque samples were obtained from periodontally healthy and diseased sites using paper points. P. gingivalis colonies were isolated and tested, using an antibiotic protection assay, for their ability to invade KB cells. P. gingivalis 381 and Escherichia coli MC1061 were used as controls.
resultsMean values of 16.79 +/- 0.86 x 10(3) colony-forming units/mL and 26.14 +/- 2.11 x 10(3) colony-forming units/mL were observed in invasion assays for isolates from periodontally healthy and diseased sites, respectively. P. gingivalis present in diseased sites had significantly greater invasive abilities than strains isolated from healthy sites. No statistical difference was noted between male or female subjects concerning the degree of invasion; isolates from diseased sites from both genders had significantly greater invasion abilities than those from healthy sites. A significant correlation was found between the increased invasive capabilities of P. gingivalis isolates vs. an increased probing depth.
conclusionThe increased invasion noted with P. gingivalis isolates from diseased sites vs. healthy sites, and the increased invasive capabilities with increasing probing depth, indicate that P. gingivalis isolates have a varying ability to invade host cells in the periodontal pocket.
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