ArticleAlimentary pharmacology & therapeutics2008
Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndrome.
Article in Alimentary pharmacology & therapeutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Factorial study of moxibustion in treatment of diarrhea-predominant irritable bowel syndrome.World journal of gastroenterology · 2014Trial
- On-demand treatment with alverine citrate/simeticone compared with standard treatments for irritable bowel syndrome: results of a randomised pragmatic study.International journal of clinical practice · 2014Trial
- Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome: a randomized, double-blind study.World journal of gastroenterology · 2012Trial
- Bladder Pain Sensitivity Is a Potential Risk Factor for Irritable Bowel Syndrome.Digestive diseases and sciences · 2023Article
- Irritable bowel syndrome: Factors of importance for disease-specific quality of life.United European gastroenterology journal · 2022Article
- Serotonin transporter and cholecystokinin in diarrhea-predominant irritable bowel syndrome: Associations with abdominal pain, visceral hypersensitivity and psychological performance.World journal of clinical cases · 2020Article
- Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome.World journal of gastroenterology · 2019Observational
- Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome.World journal of gastroenterology · 2018Article
- Brain functional connectivity is associated with visceral sensitivity in women with Irritable Bowel Syndrome.NeuroImage. Clinical · 2017Article
- Treatment of abdominal pain in irritable bowel syndrome.Journal of gastroenterology · 2014Review
- The bile acid TGR5 membrane receptor: from basic research to clinical application.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2014Review
- Translation and psychometric evaluation of the Chinese version of functional digestive disorders quality of life questionnaire.Digestive diseases and sciences · 2014Article
- Is irritable bowel syndrome an organic disorder?World journal of gastroenterology · 2014Review
- Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome.Gastroenterology · 2012Article
- Differences in cerebral response to esophageal acid stimuli and psychological anticipation in GERD subtypes--an fMRI study.BMC gastroenterology · 2011Article
- Ischemic hypersensitivity in irritable bowel syndrome patients.Pain medicine (Malden, Mass.) · 2010Article
- Article
- Thermal hypersensitivity in a subset of irritable bowel syndrome patients.World journal of gastroenterology · 2009Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRelationships between pain threshold during rectal distension and both symptoms intensity and alteration in quality of life (QoL) in irritable bowel syndrome (IBS) patients have been poorly evaluated.
aimTo evaluate relationships between rectal sensitivity, IBS symptom intensity and QoL in a multicentre prospective study.
methodsRectal threshold for moderate pain was measured during rectal distension in IBS patients (Rome II), while IBS symptoms intensity was assessed by a validated questionnaire and QoL by the Functional Digestive Disorder Quality of Life questionnaire.
resultsSixty-eight patients (44.2 +/- 12.7 years, 48 women) were included. The mean rectal distending volume for moderate pain was 127 +/- 35 mL while 45 patients (66%) had rectal hypersensitivity (pain threshold <140 mL). Rectal threshold was not significantly related either to overall IBS intensity score (r = -0.66, P = 0.62) or to its different components, or to FDDQL score (r = 0.30, P = 0.14). Among FDDQL domains, only anxiety (r = 0.30, P = 0.01) and coping (r = 0.31, P = 0.009) were significantly related with pain threshold.
conclusionsIn this study, two-thirds of IBS patients exhibited rectal hypersensitivity. No significant correlation was found between rectal threshold and either symptom intensity or alteration in QoL.
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