Evidence map›Paper›PMID 18544011›Full record

ArticleThe Journal of infectious diseases2008

Human T lymphotropic virus type 1 infection and gastric cancer development in Japan.

Satohiro Matsumoto, Kazumi Yamasaki, Kenichiro Tsuji, Satoshi Shirahama

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Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  10. Viral commensalism in humans?The Journal of infectious diseases · 2008
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Satohiro MatsumotoDepartment of Internal Medicine, Kamigoto Hospital, Japan. hiyo-mana@gol.com
Kazumi Yamasaki
Kenichiro Tsuji
Satoshi Shirahama

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe rate of human T lymphotropic virus type 1 (HTLV-1) positivity among residents of Kamigoto, Japan, is extremely high (15%). Although the rate of Helicobacter pylori positivity in Kamigoto is almost the same as that in other areas of Japan, the incidence of gastric cancer in Kamigoto is lower. This study examined whether HTLV-1 infection affects H. pylori infection and the development of gastric cancer.

methodsThe study involved 5686 patients >40 years of age who provided serum specimens for HTLV-1 antibody testing during 1989-1992. A total of 1812 patients underwent gastric endoscopy during the follow-up period. Of these, 497 were HTLV-1 seropositive. Data for these patients were compared with those for 497 HTLV-1-seronegative control patients matched for age, sex, and follow-up duration. We followed these groups until 2003 and determined the cumulative incidence rate of gastric cancer.

resultsThe rate of H. pylori positivity was 61.7% in the HTLV-1-positive group and 71.6% in the HTLV-1-negative group (P = .07). Fourteen HTLV-1-positive patients (2.8%) had gastric cancer, compared with 35 patients (7.0%) in the HTLV-1-negative group (odds ratio, 0.38; 95% confidence interval, 0.21-0.70; P = .0028).

conclusionHTLV-1 infection likely reduces the risk of H. pylori infection and proliferation and, thereby, the risk of gastric cancer.

Indexed as

Helicobacter pyloriAdultAgedAged, 80 and overCase-Control StudiesCohort StudiesFemaleHelicobacter InfectionsHTLV-I AntibodiesHTLV-I InfectionsHumansHuman T-lymphotropic virus 1IncidenceJapanMaleMiddle AgedHTLV-I Antibodies

Identifiers

PMID18544011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.