Evidence map›Paper›PMID 1854341›Full record

ArticleThe Biochemical journal1991

The Id gene is activated by serum but is not required for de-differentiation in rat vascular smooth muscle cells.

P R Kemp, D J Grainger, C M Shanahan, P L Weissberg, J C Metcalfe

Abstract read
In one paragraph

Article in The Biochemical journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

P R KempDepartment of Biochemistry, University of Cambridge, U.K.
D J Grainger
C M Shanahan
P L Weissberg
J C Metcalfe

Funding

Wellcome Trust
6 · The paper itself

Abstract

Primary rat vascular smooth muscle cells cultured on fibronectin in the absence of serum lost smooth-muscle-specific myosin heavy chain but did not enter the cell cycle and proliferate until they were stimulated by serum. Under these conditions accumulation of Id mRNA occurred only in response to serum and was maximal during the G1 phase of the cycle.

Indexed as

Gene Expression RegulationAnimalsAortaBloodCell DifferentiationCells, CulturedCulture MediaDNA ReplicationKineticsMuscle, Smooth, VascularMyosinsRatsRats, Inbred StrainsTime FactorsCulture MediaMyosins

Identifiers

PMID1854341
PMCPMC1151222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.