ArticleGenesis (New York, N.Y. : 2000)2008
Cre-mediated recombination in mouse Clara cells.
Article in Genesis (New York, N.Y. : 2000), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 32 citations in OpenAlex.
- Repurposing of the Macrolide Antibiotic Clarithromycin for the Prevention of Lung Cancer.Molecular cancer therapeutics · 2026Article
- Tristetraprolin protects against ozone-induced acute lung injury and inflammation in mice.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Lineage Tracing of Distal Lung Epithelial Progenitors in Injury-Induced Regeneration.The clinical respiratory journal · 2025Review
- Long-term exposure to house dust mites accelerates lung cancer development in mice.Journal of experimental & clinical cancer research : CR · 2023Article
- Deletion of Miro1 in airway club cells potentiates allergic asthma phenotypes.Frontiers in allergy · 2023Article
- Article
- Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease.Frontiers in immunology · 2022Article
- Neuroendocrine Lung Cancer Mouse Models: An Overview.Cancers · 2020Review
- TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.Nature cell biology · 2019Article
- Autophagy proteins are required for club cell structure and function in airways.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Airway Epithelial Cell Peroxisome Proliferator-Activated Receptor γ Regulates Inflammation and Mucin Expression in Allergic Airway Disease.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.The Journal of clinical investigation · 2018Article
- Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.Mucosal immunology · 2016Article
- MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression.Oncogene · 2016Article
- Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration.Nature · 2015Article
- Keeping it together: Pulmonary alveoli are maintained by a hierarchy of cellular programs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis.Cell reports · 2015Article
- An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.Nature medicine · 2014Article
- T helper 17 cells play a critical pathogenic role in lung cancer.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Clara cells are nonciliated secretory cells lining the respiratory epithelium and are easily identified by the expression of Clara cell secretory protein (CCSP). To investigate molecular mechanism(s) regulating Clara cell function in the lungs, Cre recombinase was inserted into exon 1 of the CCSP, generating two novel mouse models, CCSP(Cre-Neo) and CCSP(Cre). These two models differ only by the inclusion of the neomycin resistance gene. These mice were bred to the R26R reporter mouse to investigate the tissue and cell specificity of Cre-mediated recombination. The efficiency of Cre recombination in the CCSP(Cre) mouse model was higher than in the CCSP(Cre-Neo) mouse model. Recombination was detected at D 4.5 in CCSP(Cre-Neo)/R26R mice and at D 0.5 in CCSP(Cre)/R26R mice. The CCSP(Cre-Neo) and CCSP(Cre) mouse models provide valuable tools for the ablation of genes in the postnatal mouse Clara cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.