Trial reportPediatric nephrology (Berlin, Germany)2008
Doppler assessment of brachial artery flow as a measure of endothelial dysfunction in pediatric chronic renal failure.
Trial report in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Role of hypertension in progression of pediatric CKD.Pediatric nephrology (Berlin, Germany) · 2023Review
- Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease.Children (Basel, Switzerland) · 2022Review
- Endothelial Dysfunction in Childhood Cancer Survivors: A Narrative Review.Life (Basel, Switzerland) · 2021Review
- Oxidative stress in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Dyslipidemia, carotid intima-media thickness and endothelial dysfunction in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2016Article
- Endothelial Function in Patients with Hematologic Malignancies Undergoing High-Dose Chemotherapy Followed by Hematopoietic Stem Cell Transplantation.Cardiovascular toxicology · 2016Article
- Effect of long-term Vitamin C intake on vascular endothelial function in diabetic children and adolescents: A pilot study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Article
- Effect of vitamin C on endothelial function of children with chronic renal failure: An experimental study.Advanced biomedical research · 2015Article
- Cardiovascular risk assessment in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- Peripheral vascular dysfunction in chronic kidney disease.Cardiology research and practice · 2011Article
- Dyslipidemia in children with chronic kidney disease.Kidney international · 2010Article
- Cardiovascular disease in children with CKD or ESRD.Nature reviews. Nephrology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular morbidity and mortality are highly prevalent among patients with chronic renal failure (CRF). Endothelial dysfunction is regarded as the initial reversible step in the development of atherosclerosis and has been demonstrated in all stages of renal failure. Non-invasive techniques to assess endothelial function have been recently developed and have been proven to predict future mortality in adults. We aimed to assess endothelial function in children with stage 4 chronic kidney disease (CKD 4) on conservative treatment, using a-non invasive, high-resolution, ultrasound Doppler study of the brachial artery flow, correlating it with other clinical and laboratory parameters. This study included 34 children with CKD 4 on conservative treatment who were compared with 30 healthy controls. Flow-mediated dilatation (FMD), nitroglycerin-mediated dilatation (NTG-MD) and FMD/NTG-MD ratio were estimated. FMD was abnormal (< 5%) in 24 patients (71%). FMD and FMD/NTG-MD ratio were significantly lower in patients than in controls (P = 0.001 and P = 0.01, respectively). FMD correlated positively with serum calcium and negatively with alkaline phosphatase. We concluded that endothelial dysfunction is present in children with CKD 4 on conservative treatment and may reflect increased atherogenic and thrombogenic properties of the endothelium, contributing to subsequent adverse cardiovascular outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.