ArticlePsychopharmacology2008
Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men.Neuroscience letters · 2010Trial
- Effects of Serotonin Transporter Genotype and (Un)Predictable Maternal Separation on Affective, Cognitive, and Social Behaviors in Female Rats.Genes, brain, and behavior · 2026Article
- Article
- Tryptophan Improves Memory Independent of Its Role as a Serotonin Precursor: Potential Involvement of Microtubule Proteins.Journal of molecular neuroscience : MN · 2020Article
- Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats.Pharmaceuticals (Basel, Switzerland) · 2018Article
- Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.Psychopharmacology · 2018Article
- Brain hyperserotonemia causes autism-relevant social deficits in mice.Molecular autism · 2018Article
- The Serotonin Transporter and Early Life Stress: Translational Perspectives.Frontiers in cellular neuroscience · 2017Review
- Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Nicotine Administration Attenuates Methamphetamine-Induced Novel Object Recognition Deficits.The international journal of neuropsychopharmacology · 2015Article
- Acute tryptophan depletion reduces nitric oxide synthase in the rat hippocampus.Neurochemical research · 2013Article
- Serotonin transporter gene moderates associations between mood, memory and hippocampal volume.Behavioural brain research · 2013Article
- Methamphetamine-induced changes in the object recognition memory circuit.Neuropharmacology · 2012Article
- Mechanism of acute tryptophan depletion: is it only serotonin?Molecular psychiatry · 2011Review
- Fluoxetine exerts age-dependent effects on behavior and amygdala neuroplasticity in the rat.PloS one · 2011Article
- Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions.PloS one · 2011Article
- Monoamine transporters: vulnerable and vital doorkeepers.Progress in molecular biology and translational science · 2011Review
- Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.PloS one · 2009Article
- Relationships among body mass, brain size, gut length, and blood tryptophan and serotonin in young wild-type mice.BMC physiology · 2009Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAcute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats.
objectivesAs individual differences exist in central serotonin neurotransmission, the impact of ATD may vary accordingly. In this experiment, we investigated the hypothesis that male serotonin transporter knockout (SERT(-/-)), rats marked by a lower SERT function, are more vulnerable to the effects of ATD in an object recognition task than male wildtype (SERT(+/+)) and heterozygous (SERT(+/-)) rats. MATERIALS AND
methodsTwelve male SERT(+/+), SERT(+/-), and SERT(-/-) rats were treated with standard dose and low-dose ATD using a gelatine-based protein-carbohydrate mixture lacking tryptophan. In the control treatment, L: -tryptophan was added to the mixture. Four hours after treatment, the rats were subjected to the object recognition task. In addition, the effects of ATD on plasma amino acid concentrations were measured, and concentrations of 5-HT and 5-HIAA were measured in the frontal cortex and hippocampus of these rats.
resultsPlasma TRP levels and central 5-HT and 5-HIAA levels were decreased in all genotypes after ATD, but effects were stronger in SERT(-/-) rats. The standard dose of ATD impaired object recognition in all genotypes. SERT(-/-) and SERT(+/-) rats were more vulnerable to low dose of ATD in the object recognition task compared to SERT(+/+) rats.
conclusionsThese results indicate a greater sensitivity to ATD in SERT(-/-) and SERT(+/-) rats, which may be related to stronger central depletion effects in these rats.
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