Trial reportClinical research in cardiology : official journal of the German Cardiac Society2008
Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03644446 (Bisoprolol Plasma Residual Concentrations for the Optimization of Drug Management in Heart Failure With Mild to Reduced Ejection Fraction), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bisoprolol Plasma Residual Concentrations for the Optimization of Drug Management in Heart Failure With Mild to Reduced Ejection Fraction
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Neurohormonal activation and inflammation in chronic cardiopulmonary disease: a brief systematic review.Wiener klinische Wochenschrift · 2009Pooled it
- Regional differences in health-related quality of life in elderly heart failure patients: results from the CIBIS-ELD trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Trial
- Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial.European journal of heart failure · 2011Trial
- Baseline Blood Pressure and Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy with Spontaneous Mechanical Alternans.Internal medicine (Tokyo, Japan) · 2023Observational
- Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure.Scientific reports · 2021Article
- Incremental prognostic value of a novel metabolite-based biomarker score in congestive heart failure patients.ESC heart failure · 2020Article
- Dilated cardiomyopathy with re-worsening left ventricular ejection fraction.Heart and vessels · 2019Article
- Cardiac fibrosis detected by magnetic resonance imaging on predicting time course diversity of left ventricular reverse remodeling in patients with idiopathic dilated cardiomyopathy.Heart and vessels · 2016Observational
- Prognostic significance of beta-blocker up-titration in conjunction with cardiac resynchronization therapy in heart failure management.Heart and vessels · 2016Observational
- Time course of left ventricular reverse remodeling in response to pharmacotherapy: clinical implication for heart failure prognosis in patients with idiopathic dilated cardiomyopathy.Heart and vessels · 2016Observational
- Validation of the FEW16 questionnaire for the assessment of physical well-being in patients with heart failure with reduced ejection fraction: results from the CIBIS-ELD study.ESC heart failure · 2015Article
- Clinical significance of heart rate during acute decompensated heart failure to predict left ventricular reverse remodeling and prognosis in response to therapies in nonischemic dilated cardiomyopathy.Heart and vessels · 2014Article
- Heart failure and chronic obstructive pulmonary disease: Two for tea or tea for two?World journal of cardiology · 2010Article
- Individuals at risk of beta-blocker discontinuation: a cohort study in 19,177 Chinese patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2010Article
- Clinical variables affecting survival in patients with decompensated diastolic versus systolic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2009Article
- The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure.Wiener klinische Wochenschrift · 2009Article
- Heart failure, aging and beta-blockers: the need for more data on tolerability and efficacy.Clinical research in cardiology : official journal of the German Cardiac Society · 2008Article
Corrections and comments
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Authors and funding
19 authors at 10 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers are the mainstay of CHF therapy; yet they are under-prescribed and under-dosed in clinical practice. This is particularly evident in elderly patients, which may be due to a fear of side-effects or intolerance. Beta-blockers have further not been adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data on the use of different beta-blockers in patients with CHF is scarce.
aimTo compare the tolerance of bisoprolol and carvedilol in elderly patients with CHF.
methodsCIBIS-ELD is an investigator-initiated, multi-centre, 1:1 randomised, double-blind, phase III trial comparing bisoprolol and carvedilol in patients >or=65 years with systolic or diastolic CHF. Recruitment started in April 2005 and is anticipated to be completed by April 2008 with at least 800 patients enrolled. PERSPECTIVE: This is the first large scale head to head beta-blockers trial in an elderly population with CHF. Besides determining which of two standard beta-blockers is best tolerated in elderly patients with systolic or diastolic CHF, we expect to gain further insight into the treatment of the particular population of patients with diastolic CHF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.