ArticleAntimicrobial agents and chemotherapy1991
Modulation of the intestinal flora of mice by parenteral treatment with broad-spectrum cephalosporins.
Article in Antimicrobial agents and chemotherapy, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens.Antimicrobial agents and chemotherapy · 2019Trial
- Pre-existing β-lactamase gene diversity is associated with lower risk of ESBL-producing Enterobacterales colonization in patients exposed to ceftriaxone.Gut microbes · 2026Article
- Article
- In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes.The European respiratory journal · 2023Article
- MiniBioReactor Array (MBRA)JAC-antimicrobial resistance · 2022Article
- Interactions betweenFrontiers in microbiology · 2022Review
- Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis.Infection and immunity · 2012Article
- Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice.Antimicrobial agents and chemotherapy · 2011Article
- Shifting the balance: antibiotic effects on host-microbiota mutualism.Nature reviews. Microbiology · 2011Review
- Host and microbiota factors that control Klebsiella pneumoniae mucosal colonization in mice.Microbes and infection · 2008Article
- Effect of a selective decontamination of the digestive tract regimen including parenteral cefepime on establishment of intestinal colonization with vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice.Antimicrobial agents and chemotherapy · 2006Article
- Antibiotics and gastrointestinal colonization by vancomycin-resistant enterococci.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2005Review
- Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases.Antimicrobial agents and chemotherapy · 2003Article
- Natural pathogens of laboratory mice, rats, and rabbits and their effects on research.Clinical microbiology reviews · 1998Review
- Gastrointestinal colonization by methicillin-resistant Staphylococcus aureus in immunosuppressed mice.Infection and immunity · 1996Article
- Selective decontamination in bone marrow transplant recipients.Epidemiology and infection · 1992Review
- Modulation of the intestinal flora of mice by treatment with aztreonam and tigemonam.Antimicrobial agents and chemotherapy · 1991Article
- Preclinical Rodent Toxicity Studies for Long Term Use of Ceftriaxone.Toxicology reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A study was performed to determine the effect of parenteral treatment with four broad-spectrum cephalosporins (cefoperazone, ceftriaxone, ceftazidime, and cefepime) on the number of aerobic gram-negative rods and on the outgrowth of Candida albicans and a multiresistant strain of Citrobacter freundii in the feces of mice. The estimated fractions of a parenteral dose that were excreted into the gastrointestinal tract were 0.37 for cefoperazone, 0.11 for ceftriaxone, 0.03 for ceftazidime, and 0.002 for cefepime. All four cephalosporins significantly decreased the number of aerobic gram-negative rods in the feces, and virtually all gram-negative rods were eliminated at high doses of cefoperazone, ceftazidime, and ceftriaxone. Furthermore, at high doses these three compounds led to a significant increase of the outgrowth of resistant Citrobacter freundii. The outgrowth of Candida albicans was increased at high doses of cefoperazone and ceftriaxone, whereas ceftazidime and cefepime did not have this effect. The most profound changes in the gastrointestinal ecology were observed during treatment with high doses of cefoperazone. The results suggest that the colonization resistance of the gastrointestinal tract can be substantially decreased by parenteral treatment with cefoperazone and, to a lesser extent, with ceftriaxone and ceftazidime.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.