ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2008
Pax7 shows higher satellite cell frequencies and concentrations within intrafusal fibers of muscle spindles.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- PAX3-SIX2 muscle stem cell heterogeneity drives muscle-specific repair dynamics diversification.Science advances · 2026Article
- A who's who of cell types in skeletal muscle.Communications biology · 2026Review
- The evolution of muscle spindles.Experimental physiology · 2025Review
- Differential response of oxidative and glycolytic skeletal muscle fibers to mesterolone.Scientific reports · 2021Article
- Article
- Neuregulin 1 Drives Morphological and Phenotypical Changes in C2C12 Myotubes: TowardsFrontiers in cell and developmental biology · 2021Article
- Featured characteristics and pivotal roles of satellite cells in skeletal muscle regeneration.Journal of muscle research and cell motility · 2020Article
- Histological study of postnatal development of mouse tongues.Experimental and therapeutic medicine · 2018Article
- Reduced voluntary running performance is associated with impaired coordination as a result of muscle satellite cell depletion in adult mice.Skeletal muscle · 2015Article
- Myogenic-specific ablation of Fgfr1 impairs FGF2-mediated proliferation of satellite cells at the myofiber niche but does not abolish the capacity for muscle regeneration.Frontiers in aging neuroscience · 2015Article
- The skeletal muscle satellite cell: still young and fascinating at 50.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Heterogeneity in the muscle satellite cell population.Seminars in cell & developmental biology · 2010Review
- Retention of Pax3 expression in satellite cells of muscle spindles.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Review
- Generating intrafusal skeletal muscle fibresJournal of tissue engineeringReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Intrafusal fibers within muscle spindles make up a small subpopulation of muscle fibers. These proprioceptive fibers differ from most extrafusal fibers because, even in maturity, their diameters remain small, and they retain expression of developmental myosins. Although both extrafusal and intrafusal fibers contain satellite cells (SCs), comparatively little is known about intrafusal SCs. Analyzing chicken fast-phasic posterior (PLD) and slow-tonic anterior (ALD) latissimus dorsi muscles, we show that SCs of both intrafusal and extrafusal fibers express Pax7. We further test the hypotheses that intrafusal fibers display parameters reflective of extrafusal immaturity. These hypotheses are that intrafusal fibers contain (a) higher SC frequencies (number of SC nuclei/all nuclei within basal lamina) and concentrations (closer together) and (b) smaller myonuclear domains than do adjacent extrafusal fibers. IHC techniques were applied to PLD and ALD muscles excised at 30 and 138 days posthatch. The hypotheses were validated, suggesting that intrafusal fibers have greater capacities for growth, regeneration, and repair than do adjacent extrafusal fibers. During maturation, extrafusal and intrafusal fibers show similar trends of decreasing SC frequencies and concentrations and increases in myonuclear domains. Thus, extrafusal and intrafusal fibers alike should exhibit reduced capacities for growth, regeneration, and repair during maturation.
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Registered trials
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