ArticleInfection and immunity2008
An interleukin-1beta (IL-1beta) single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of IL-1beta in diseased periodontal tissues.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Diagnostic tests for titanium hypersensitivity in implant dentistry: a systematic review of the literature.International journal of implant dentistry · 2022Pooled it
- Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis.Medicine · 2017Pooled it
- Trial
- Innate Immunity Gene Variants Affect Periodontitis Susceptibility.Advances in experimental medicine and biology · 2026Article
- Loss of Fine Motor Dexterity and Reduced Oral Hygiene 15 Years After Diagnosis of Multifocal Motor Neuropathy with Screw-Retained Implant-Supported Rehabilitation: Literature Review and Case Report.Oral health & preventive dentistry · 2024Review
- The Diagnostic and Prognostic Role of Interleukin 6 and Interleukin 8 in Childhood Acute Gastroenteritis-A Review of the Literature.International journal of molecular sciences · 2024Review
- Genetic Control of GCF Exudation: Innate Immunity Genes and Periodontitis Susceptibility.International journal of molecular sciences · 2023Article
- IL-1B(3954) polymorphism and red complex bacteria increase IL-1β (GCF) levels in periodontitis.Journal of periodontal research · 2021Article
- Comparison of salivary cytokines levels among individuals with Down syndrome, cerebral palsy and normoactive.Journal of clinical and experimental dentistry · 2020Article
- Periodontal inflammation: Integrating genes and dysbiosis.Periodontology 2000 · 2020Review
- To P or not to P, is that the question? Rethinking experimental design and data analysis to improve biological significance beyond the statistical significance.Journal of applied oral science : revista FOB · 2019Article
- Interleukin-10 polymorphisms affect the key periodontal pathogens in Chinese periodontitis patients.Scientific reports · 2018Article
- Article
- Periodontal Infectogenomics.Inflammation and regeneration · 2018Review
- Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editing.Scientific reports · 2016Article
- HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients.Mediators of inflammation · 2015Article
- Green Tea Modulates Cytokine Expression in the Periodontium and Attenuates Alveolar Bone Resorption in Type 1 Diabetic Rats.PloS one · 2015Article
- Article
- Severe periodontal disease associated with long-term treatment with intravenous immunoglobulin.Case reports in dentistry · 2014Article
- Periodontopathogens levels and clinical response to periodontal therapy in individuals with the interleukin-4 haplotype associated with susceptibility to chronic periodontitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory cytokines such as interleukin-1beta (IL-1beta) are involved in the pathogenesis of periodontal diseases. A high individual variation in the levels of IL-1beta mRNA has been verified, which is possibly determined by genetic polymorphisms and/or by the presence of periodontopathogens such as Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Aggregatibacter actinomycetemcomitans. In this study, we investigated the role of an IL-1beta promoter single-nucleotide polymorphism at position 3954 [IL-1beta(3954) SNP] and the presence of the periodontopathogens in the determination of the IL-1beta levels in the periodontal tissues of nonsmoking chronic periodontitis (CP) patients (n = 117) and control (C) subjects (n = 175) and the possible correlations with the clinical parameters of the disease. IL-1beta(3954) SNP was investigated by restriction fragment length polymorphism, while the IL-1beta levels and the presence of the periodontopathogens were determined by real-time PCR. Similar frequencies of IL-1beta(3954) SNP were found in the C and CP groups, in spite of a trend toward a higher incidence of T alleles in the CP group. The IL-1beta(3954) SNP CT and TT genotypes, as well as P. gingivalis, T. forsythia, and T. denticola, were associated with higher IL-1beta levels and with higher values of the clinical parameters of disease severity. Concomitant analyses demonstrate that IL-1beta(3954) and the red complex periodontopathogens were found to independently and additively modulate the levels of IL-1beta in periodontal tissues. Similarly, the concurrent presence of both factors was associated with increased scores of disease severity. IL-1beta(3954) genotypes and red complex periodontopathogens, individually and additively, modulate the levels of IL-1beta in the diseased tissues of nonsmoking CP patients and, consequently, are potentially involved in the determination of the disease outcome.
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