ArticleInfection and immunity2008
Identification of two translocon proteins of Vibrio parahaemolyticus type III secretion system 2.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Class II chaperones: indispensable components of the Gram-negative bacterial T3SS as guardians of translocators.Archives of microbiology · 2026Review
- Role of the TPR family protein VPA1365 in regulating type III secretion system 2 and virulence inApplied and environmental microbiology · 2025Article
- Genomic and pathogenicity analyses to identify the causative agent from multiple serogroups of non-O1, non-O139Microbial genomics · 2025Article
- Transcriptome Analysis Reveals the Effect of Low NaCl Concentration on Osmotic Stress and Type III Secretion System inInternational journal of molecular sciences · 2023Article
- Article
- The Antimicrobial Effect ofFrontiers in microbiology · 2022Article
- Whole genome analysis unveils genetic diversity and potential virulence determinants inVirulence · 2021Article
- Zebrafish Models for Pathogenic Vibrios.Journal of bacteriology · 2020Review
- Export of a Vibrio parahaemolyticus toxin by the Sec and type III secretion machineries in tandem.Nature microbiology · 2019Article
- CRISPR-Cas systems are present predominantly on mobile genetic elements in Vibrio species.BMC genomics · 2019Article
- Vibrio variations on a type three theme.Current opinion in microbiology · 2019Review
- Article
- Gene expression of Vibrio parahaemolyticus growing in laboratory isolation conditions compared to those common in its natural ocean environment.BMC microbiology · 2017Article
- Genetic analysis of Vibrio parahaemolyticus intestinal colonization.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Interaction between the type III effector VopO and GEF-H1 activates the RhoA-ROCK pathway.PLoS pathogens · 2015Article
- Suicide plasmid-dependent IS1-element untargeted integration into Aeromonas veronii bv. sobria generates brown pigment-producing and spontaneous pelleting mutant.Current microbiology · 2013Article
- A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation.Cell reports · 2013Article
- The role of type III secretion system 2 in Vibrio parahaemolyticus pathogenicity.Journal of microbiology (Seoul, Korea) · 2012Review
- The hydrophilic translocator for Vibrio parahaemolyticus, T3SS2, is also translocated.Infection and immunity · 2012Article
- Comparative genomic analysis of Vibrio parahaemolyticus: serotype conversion and virulence.BMC genomics · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The type III secretion system (T3SS) translocon complex is composed of several associated proteins, which form a translocation channel through the host cell plasma membrane. These proteins are key molecules that are involved in the pathogenicity of many T3SS-positive bacteria, because they are necessary to deliver effector proteins into host cells. A T3SS designated T3SS2 of Vibrio parahaemolyticus is thought to be related to the enterotoxicity of this bacterium in humans, but the effector translocation mechanism of T3SS2 is unclear because there is only one gene (the VPA1362 gene) in the T3SS2 region that is homologous to other translocon protein genes. It is also not known whether the VPA1362 protein is functional in the translocon of T3SS2 or whether it is sufficient to form the translocation channel of T3SS2. In this study, we identified both VPA1362 (designated VopB2) and VPA1361 (designated VopD2) as T3SS2-dependent secretion proteins. Functional analysis of these proteins showed that they are essential for T3SS2-dependent cytotoxicity, for the translocation of one of the T3SS2 effector proteins (VopT), and for the contact-dependent activity of pore formation in infected cells in vitro. Their targeting to the host cell membrane depends on T3SS2, and furthermore, they are necessary for T3SS2-dependent enterotoxicity in vivo. These results indicate that VopB2 and VopD2 act as translocon proteins of V. parahaemolyticus T3SS2 and hence have a critical role in the T3SS2-dependent enterotoxicity of this bacterium.
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