Trial reportThe American journal of clinical nutrition2008
Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects.
Trial report in The American journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Plasma alkylresorcinols as a biomarker of whole-grain food consumption in a large population: results from the WHOLEheart Intervention Study.The American journal of clinical nutrition · 2012Trial
- Urinary α-Carboxyethyl Hydroxychromanol (α-CEHC)-A Biomarker of Vitamin E Intake: A Scoping Review.The Journal of nutrition · 2026Article
- Scientific opinion on the tolerable upper intake level for vitamin E.EFSA journal. European Food Safety Authority · 2024Article
- Impact of vitamin E on redox biomarkers in non-alcoholic fatty liver disease.Redox biology · 2021Review
- Tocopherols and Tocotrienols Are Bioavailable in Rats and Primarily Excreted in Feces as the Intact Forms and 13'-Carboxychromanol Metabolites.The Journal of nutrition · 2020Article
- Pharmacokinetics of vitamin E, γ-oryzanol, and ferulic acid in healthy humans after the ingestion of a rice bran-enriched porridge prepared with water or with milk.European journal of nutrition · 2019Article
- New alkylresorcinol metabolites in spot urine as biomarkers of whole grain wheat and rye intake in a Swedish middle-aged population.European journal of clinical nutrition · 2018Article
- Evaluation of alkylresorcinols in adipose tissue biopsies as a long-term biomarker of whole-grain wheat and rye intake in free-living Swedish men and women.Public health nutrition · 2018Article
- GC-MS Based Metabolomics and NMR Spectroscopy Investigation of Food Intake Biomarkers for Milk and Cheese in Serum of Healthy Humans.Metabolites · 2018Article
- Complexity of vitamin E metabolism.World journal of biological chemistry · 2016Review
- Effects of Dietary Honey andArdehCombination on Chemotherapy- Induced Gastrointestinal and Infectious Complications in Patients with Acute Myeloid Leukemia: A Double-Blind Randomized Clinical Trial.Iranian journal of pharmaceutical research : IJPR · 2016Article
- α-Tocopherol does not accelerate depletion of γ-tocopherol and tocotrienol or excretion of their metabolites in rats.Lipids · 2013Article
- Long-term reproducibility of plasma alkylresorcinols as biomarkers of whole-grain wheat and rye intake within Northern Sweden Health and Disease Study Cohort.European journal of clinical nutrition · 2013Article
- Bioavailability of bioactive food compounds: a challenging journey to bioefficacy.British journal of clinical pharmacology · 2013Review
- Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.The Journal of nutritional biochemistry · 2010Article
- Reliability of fasting plasma alkylresorcinol concentrations measured 4 months apart.European journal of clinical nutrition · 2010Article
- Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.Molecular cancer research : MCR · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundGamma-tocopherol has unique properties that may be beneficial in sustaining optimal human health, but hepatic vitamin E metabolism enhances gamma-tocopherol turnover.
objectiveOur aim was to determine the extent to which dietary sesame lignans alter human alpha- and gamma-tocopherol metabolism and elimination as carboxyethyl hydroxychromanols (CEHCs).
designHealthy participants (n = 5 women and 5 men) in a randomized, crossover study (with 4-wk washout) consumed muffins prepared with either corn oil or unrefined sesame oil (sesamin, 94 mg; sesamolin, 42 mg), along with a capsule containing a 1:1 molar ratio of deuterium-labeled d(6)-alpha- and d(2)-gamma-tocopherol acetates ( approximately 50 mg each). Plasma and urine were collected up to 72 h; unlabeled and labeled tocopherol and CEHC concentrations were determined by liquid chromatography-mass spectrometry.
resultsSesame oil muffin consumption in men, but not in women, decreased (P < 0.05) areas under plasma d(2)-gamma-CEHC concentration-time curves (area under the curve) and maximum concentrations. However, in both sexes urinary d(2)-gamma-CEHCs were decreased for 24 h following sesame oil muffin consumption.
conclusionsIn humans, gamma-tocopherol metabolism can be inhibited by the simultaneous consumption of gamma-tocopherol and sesame lignans. The observed differences between men and women with respect to vitamin E metabolism warrant further investigation.
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