Evidence map›Paper›PMID 18541289›Full record

ReviewMechanisms of ageing and development

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging.

Tinna Stevnsner, Meltem Muftuoglu, Maria Diget Aamann, Vilhelm A Bohr

Open access · greenAbstract readReview
In one paragraph

Review in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 128 citations in OpenAlex.

  1. Article
  2. Review
  3. Mitochondria-Nuclear Crosstalk: Orchestrating mtDNA Maintenance.Environmental and molecular mutagenesis · 2025
    Review
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  5. Article
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Tinna StevnsnerDanish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, C.F. Møllers Allé, Aarhus C, Denmark. tvs@mb.au.dk
Meltem Muftuoglu
Maria Diget Aamann
Vilhelm A Bohr
Aarhus University · DKNational Institute on Aging · US

Funding

Function of RecQ helicases in genome stabilityZ01AG000726 · NIA · NATIONAL INSTITUTE ON AGING · PI BOHR, VILHELM A · 1993 to 2008
$2.9M
REPAIR OF OXIDATIVE DNA DAMAGEZ01AG000727 · NIA · NATIONAL INSTITUTE ON AGING · PI BOHR, VILHELM A · 1994 to 2008
$1.3M
Intramural NIH HHS Z01 AG000726Intramural NIH HHS Z01 AG000727
6 · The paper itself

Abstract

Cockayne Syndrome (CS) is a rare human genetic disorder characterized by progressive multisystem degeneration and segmental premature aging. The CS complementation group B (CSB) protein is engaged in transcription coupled and global nucleotide excision repair, base excision repair and general transcription. However, the precise molecular function of the CSB protein is still unclear. In the current review we discuss the involvement of CSB in some of these processes, with focus on the role of CSB in repair of oxidative damage, as deficiencies in the repair of these lesions may be an important aspect of the premature aging phenotype of CS.

Indexed as

DNA RepairAgingAging, PrematureChromatinCockayne SyndromeDNA DamageDNA HelicasesDNA Repair EnzymesHumansPoly-ADP-Ribose Binding ProteinsChromatinDNA HelicasesDNA Repair EnzymesERCC6 protein, humanPoly-ADP-Ribose Binding Proteins

Identifiers

PMID18541289
PMCPMC2538557
OpenAlexW2077690563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.