Evidence map›Paper›PMID 18541218›Full record

ReviewCell host & microbe2008

Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases.

Daniel A Peterson, Daniel N Frank, Norman R Pace, Jeffrey I Gordon

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 251 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
251citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

251 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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191 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel A PetersonCenter for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.
Daniel N Frank
Norman R Pace
Jeffrey I Gordon

Funding

Trace the flow of genes in the gut microbiome of obese and lean twin pairsP01DK078669 · NIDDK · WASHINGTON UNIVERSITY · PI BAIN, JAMES · 2007 to 2018
$16.0M
REGULATION OF GENE EXPRESSION IN THE SMALL INTESTINER37DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 1993 to 2015
$4.0M
NIDDK NIH HHS P01 DK078669NIDDK NIH HHS R37 DK030292
6 · The paper itself

Abstract

The human gastrointestinal tract is home to immense and complex populations of microorganisms. Using recent technical innovations, the diversity present in this human body habitat is now being analyzed in detail. This review focuses on the microbial ecology of the gut in inflammatory bowel diseases and on how recent studies provide an impetus for using carefully designed, comparative metagenomic approaches to delve into the structure and activities of the gut microbial community and its interrelationship with the immune system.

Indexed as

Host-Pathogen InteractionsAnimalsBacteriaBiodiversityHumansImmunoglobulin AInflammatory Bowel DiseasesIntestinal MucosaMiceProbioticsImmunoglobulin A

Identifiers

PMID18541218
PMCPMC2872787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.