ReviewCurrent neurology and neuroscience reports2008
Genetics of restless legs syndrome.
Review in Current neurology and neuroscience reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of restless legs syndrome in North American and Western European populations: a systematic review.Sleep medicine · 2011Pooled it
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Effectiveness and safety of massage in the treatment of restless legs syndrome: A protocol for systematic review and meta analysis.Medicine · 2020Article
- Unraveling the Mysteries of Restless Leg Syndrome.Cureus · 2020Review
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression.PloS one · 2019Article
- Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome.Frontiers in behavioral neuroscience · 2018Article
- Targeted disruption of supraspinal motor circuitry reveals a distributed network underlying Restless Legs Syndrome (RLS)-like movements in the rat.Scientific reports · 2017Article
- Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome.Journal of neurology · 2017Review
- Restless Legs Syndrome: Current Concepts about Disease Pathophysiology.Tremor and other hyperkinetic movements (New York, N.Y.) · 2016Review
- The Effect of Massage With Lavender Oil on Restless Leg Syndrome in Hemodialysis Patients: A Randomized Controlled Trial.Nursing and midwifery studies · 2015Article
- The PD-associated alpha-synuclein promoter Rep1 allele 2 shows diminished frequency in restless legs syndrome.Neurogenetics · 2014Article
- A novel locus for restless legs syndrome maps to chromosome 19p in an Irish pedigree.Neurogenetics · 2012Article
- Review of the treatment of restless legs syndrome: focus on gabapentin enacarbil.Journal of central nervous system disease · 2012Article
- Evaluation of contributing factors to restless legs syndrome in migraine patients.Journal of neurology · 2011Article
- Algorithms for the diagnosis and treatment of restless legs syndrome in primary care.BMC neurology · 2011Article
- The use of rotigotine in the treatment of restless legs syndrome.Therapeutic advances in neurological disorders · 2010Article
- Clinical and genetic description of a family with a high prevalence of autosomal dominant restless legs syndrome.Mayo Clinic proceedings · 2009Article
- Restless legs syndrome: differential diagnosis and management with rotigotine.Neuropsychiatric disease and treatment · 2009Article
- [Restless legs syndrome, periodic limb movements, and psychopharmacology].Der Nervenarzt · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless legs syndrome (RLS) is a highly familial trait with heritability estimates of about 50%. It is a polygenetic disorder in which a number of variants contribute to the phenotype. Linkage studies in families with RLS revealed several loci but have not yet led to the identification of disease-causing sequence variants. Phenocopies, nonpenetrance, and possible intrafamilial heterogeneity make it difficult to define the exact candidate region. Genome-wide association studies identified variants within intronic or intergenic regions of MEIS1, BTBD9, and MAP2K5/LBOXCOR1. Carriers of one risk allele had a 50% increased risk of developing RLS. MEIS1 and LBXCOR1 are developmental factors and raise new pathophysiologic questions for RLS. These variants have weak and moderate effects and increase the risk of developing RLS. It is still possible that strong effects explain the occurrence of RLS in families. Therefore, linkage and association studies should be used congruently to dissect the complete genetic architecture of RLS.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.