ArticleBiomacromolecules2008
Integrin-adhesion ligand bond formation of preosteoblasts and stem cells in three-dimensional RGD presenting matrices.
Article in Biomacromolecules, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Enhancing the Potency of Growth Factor-Mimicking Peptides via Cross-Presentation With Integrin Ligands.Journal of biomedical materials research. Part A · 2025Article
- Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype.Biomaterials · 2021Article
- Surface Design of Antifouling Vascular Constructs Bearing Biofunctional Peptides for Tissue Regeneration Applications.International journal of molecular sciences · 2020Article
- Berberine Suppresses Fibronectin Expression through Inhibition of c-Jun Phosphorylation in Breast Cancer Cells.Journal of breast cancer · 2018Article
- Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices.Advanced healthcare materials · 2015Review
- Surface biology of collagen scaffold explains blocking of wound contraction and regeneration of skin and peripheral nerves.Biomedical materials (Bristol, England) · 2015Review
- 3D Cell Culture in Alginate Hydrogels.Microarrays (Basel, Switzerland) · 2015Review
- Control of stem cell fate by engineering their micro and nanoenvironment.World journal of stem cells · 2015Review
- Extracellular matrix as an inductive scaffold for functional tissue reconstruction.Translational research : the journal of laboratory and clinical medicine · 2014Review
- Learning from nature - novel synthetic biology approaches for biomaterial design.Acta biomaterialia · 2014Review
- Presentation of BMP-2 mimicking peptides in 3D hydrogels directs cell fate commitment in osteoblasts and mesenchymal stem cells.Biomacromolecules · 2014Article
- Fibronectin conformation regulates the proangiogenic capability of tumor-associated adipogenic stromal cells.Biochimica et biophysica acta · 2013Article
- Engineered culture models for studies of tumor-microenvironment interactions.Annual review of biomedical engineering · 2013Review
- Designing biomaterials to direct stem cell fate.ACS nano · 2012Article
- Optimizing siRNA efficacy through alteration in the target cell-adhesion substrate interaction.Journal of biomedical materials research. Part A · 2012Article
- Utilizing cell-matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels.Molecular pharmaceutics · 2011Article
- An optical method to quantify the density of ligands for cell adhesion receptors in three-dimensional matrices.Journal of the Royal Society, Interface · 2010Article
- Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds.Microscopy research and technique · 2010Article
- Tissue-engineered three-dimensional tumor models to study tumor angiogenesis.Tissue engineering. Part A · 2010Review
- Scleral reinforcement through host tissue integration with biomimetic enzymatically degradable semi-interpenetrating polymer network.Tissue engineering. Part A · 2010Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Cell-interactive polymers have been widely used as synthetic extracellular matrices to regulate cell function and promote tissue regeneration. However, there is a lack of quantitative understanding of the cell-material interface. In this study, integrin-adhesion ligand bond formation of preosteoblasts and D1 stem cells with RGD presenting alginate matrices were examined using FRET and flow cytometry. Bond number increased with adhesion ligand density but did not change with RGD island spacing for both cell types. Integrin expression varied with cell type and substrate in 2D culture, but the integrin expression profiles of both cell types were similar when cultured in 3D RGD presenting substrates and distinct from 2D culture. In summary, combining a FRET technique to quantify bond formation with flow cytometry to elucidate integrin expression can define specific cell-material interactions for a given material system and may be useful for informing biomaterial design strategies for cell-based therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.