ArticleApplied and environmental microbiology2008
Borrelia burgdorferi sensu stricto is clonal in patients with early Lyme borreliosis.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Host, vector, and parasite dynamics: exploring intrinsic and extrinsic factors shaping tick-borne filarial nematode transmission.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Machine learning-driven identification of virulence determinants in Borrelia burgdorferi associated with human dissemination.PLoS computational biology · 2026Article
- Complex exchanges among plasmids and clonal expansion of lineages shape the population structure and virulence ofbioRxiv : the preprint server for biology · 2025Article
- Population dynamics of the Lyme disease bacterium, Borrelia burgdorferi, during rapid range expansion in New York State.Molecular ecology · 2024Article
- Concurrent Infection of the Human Brain with MultipleInternational journal of molecular sciences · 2023Article
- Lyme Disease in Humans.Current issues in molecular biology · 2021Article
- Whole genome sequencing and phylogenetic analysis of strains of the agent of Lyme disease Borrelia burgdorferi from Canadian emergence zones.Scientific reports · 2018Article
- Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice.BMC microbiology · 2016Article
- Article
- Evolutionary aspects of emerging Lyme disease in Canada.Applied and environmental microbiology · 2015Review
- Molecular Typing of Borrelia burgdorferi.Current protocols in microbiology · 2014Article
- Detection of Borrelia burgdorferi sensu stricto ospC alleles associated with human lyme borreliosis worldwide in non-human-biting tick Ixodes affinis and rodent hosts in Southeastern United States.Applied and environmental microbiology · 2013Article
- Structure of rrn operons in pathogenic non-cultivable treponemes: sequence but not genomic position of intergenic spacers correlates with classification of Treponema pallidum and Treponema paraluiscuniculi strains.Journal of medical microbiology · 2013Article
- Multilocus sequence typing of Borrelia burgdorferi suggests existence of lineages with differential pathogenic properties in humans.PloS one · 2013Article
- Differentiation of reinfection from relapse in recurrent Lyme disease.The New England journal of medicine · 2012Article
- Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Review
- Borrelia burgdorferi RST1 (OspC type A) genotype is associated with greater inflammation and more severe Lyme disease.The American journal of pathology · 2011Article
- Investigation of genotypes of Borrelia burgdorferi in Ixodes scapularis ticks collected during surveillance in Canada.Applied and environmental microbiology · 2011Article
- BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle.Infection and immunity · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Lyme borreliosis, the most commonly reported vector-borne disease in North America, is caused by the spirochete Borrelia burgdorferi. Given the extensive genetic polymorphism of B. burgdorferi, elucidation of the population genetic structure of the bacterium in clinical samples may be relevant for understanding disease pathogenesis and may have applicability for the development of diagnostic tests and vaccine preparations. In this investigation, the genetic polymorphism of the 16S-23S rRNA (rrs-rrlA) intergenic spacer and ospC was investigated at the sequence level in 127 clinical isolates obtained from patients with early Lyme borreliosis evaluated in suburban New York City. Sixteen distinct rrs-rrlA and 16 distinct ospC alleles were identified, representing virtually all of the genotypes previously found in questing Ixodes scapularis nymphs in this region. In addition, a new ospC group was identified in a single patient. The strong linkage observed between the chromosome-located rrs-rrlA and plasmid-borne ospC genes suggests a clonal structure of B. burgdorferi in these isolates, despite evidence of recombination at ospC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.