ArticleBiophysical journal2008
Atomic force microscopy studies of functional and dysfunctional pulmonary surfactant films, II: albumin-inhibited pulmonary surfactant films and the effect of SP-A.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
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- Bronchopneumonia with interstitial pneumonia in beef feedlot cattle: Characterization and laboratory investigation.Veterinary pathology · 2023Article
- Protein nanoparticle-induced osmotic pressure gradients modify pulmonary edema through hyperpermeability in acute respiratory distress syndrome.Journal of nanobiotechnology · 2022Article
- Suppression of LBiophysical journal · 2021Article
- Atomic Force Microscopy Imaging of Adsorbed Pulmonary Surfactant Films.Biophysical journal · 2020Article
- Graphene-based sensing of oxygen transport through pulmonary membranes.Nature communications · 2020Article
- Electronic cigarette vapor alters the lateral structure but not tensiometric properties of calf lung surfactant.Respiratory research · 2017Article
- Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.The Journal of biological chemistry · 2014Article
- Impact of substratum surface on microbial community structure and treatment performance in biological aerated filters.Applied and environmental microbiology · 2014Article
- Self-assembled amyloid-like oligomeric-cohesin Scaffoldin for augmented protein display on the saccharomyces cerevisiae cell surface.Applied and environmental microbiology · 2012Article
- Visualizing the analogy between competitive adsorption and colloid stability to restore lung surfactant function.Biophysical journal · 2012Article
- Biophysical interaction between corticosteroids and natural surfactant preparation: implications for pulmonary drug delivery using surfactant a a carrier.Soft matter · 2012Article
- Adverse biophysical effects of hydroxyapatite nanoparticles on natural pulmonary surfactant.ACS nano · 2011Article
- On the low surface tension of lung surfactant.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Comparative study of clinical pulmonary surfactants using atomic force microscopy.Biochimica et biophysica acta · 2011Article
- Overcoming rapid inactivation of lung surfactant: analogies between competitive adsorption and colloid stability.Biochimica et biophysica acta · 2010Review
- X-ray diffraction and reflectivity validation of the depletion attraction in the competitive adsorption of lung surfactant and albumin.Biophysical journal · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary surfactant (PS) dysfunction because of the leakage of serum proteins into the alveolar space could be an operative pathogenesis in acute respiratory distress syndrome. Albumin-inhibited PS is a commonly used in vitro model for studying surfactant abnormality in acute respiratory distress syndrome. However, the mechanism by which PS is inhibited by albumin remains controversial. This study investigated the film organization of albumin-inhibited bovine lipid extract surfactant (BLES) with and without surfactant protein A (SP-A), using atomic force microscopy. The BLES and albumin (1:4 w/w) were cospread at an air-water interface from aqueous media. Cospreading minimized the adsorption barrier for phospholipid vesicles imposed by preadsorbed albumin molecules, i.e., inhibition because of competitive adsorption. Atomic force microscopy revealed distinct variations in film organization, persisting up to 40 mN/m, compared with pure BLES monolayers. Fluorescence confocal microscopy confirmed that albumin remained within the liquid-expanded phase of the monolayer at surface pressures higher than the equilibrium surface pressure of albumin. The remaining albumin mixed with the BLES monolayer so as to increase film compressibility. Such an inhibitory effect could not be relieved by repeated compression-expansion cycles or by adding surfactant protein A. These experimental data indicate a new mechanism of surfactant inhibition by serum proteins, complementing the traditional competitive adsorption mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.