ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2008
Detection of polyomavirus SV40 in tonsils from immunocompetent children.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Antibodies reacting with Simian virus 40 mimotopes in serum samples from patients with thalassaemia major.Blood transfusion = Trasfusione del sangue · 2014Trial
- Bovine Polyomavirus 2 is a Probable Cause of Non-Suppurative Encephalitis in Cattle.Pathogens (Basel, Switzerland) · 2020Article
- Antibody response to polyomavirus primary infection: high seroprevalence of Merkel cell polyomavirus and lymphoid tissue involvement.Journal of neurovirology · 2018Article
- Polyomaviruses detectable in head and neck carcinomas.Oncotarget · 2018Article
- Viral microRNA effects on persistent infection of human lymphoid cells by polyomavirus SV40.PloS one · 2018Article
- The ubiquity of asymptomatic respiratory viral infections in the tonsils and adenoids of children and their impact on airway obstruction.International journal of pediatric otorhinolaryngology · 2016Article
- Significant prevalence of antibodies reacting with simian virus 40 mimotopes in sera from patients affected by glioblastoma multiforme.Neuro-oncology · 2014Article
- Viral microRNA effects on pathogenesis of polyomavirus SV40 infections in syrian golden hamsters.PLoS pathogens · 2014Article
- Neutralizing and IgG antibodies against simian virus 40 in healthy pregnant women in Italy.PloS one · 2014Article
- Serological evidence of an early seroconversion to Simian virus 40 in healthy children and adolescents.PloS one · 2013Article
- High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Individuals infected with JC polyomavirus do not present detectable JC virus DNA in oropharyngeal fluids.The Journal of general virology · 2012Article
- Simian virus 40 transformation, malignant mesothelioma and brain tumors.Expert review of respiratory medicine · 2011Review
- Article
- Lymphotropism of Merkel cell polyomavirus infection, Nova Scotia, Canada.Emerging infectious diseases · 2010Article
- Polyomavirus infection and its impact on renal function and long-term outcomes after lung transplantation.Transplantation · 2009Article
- Polyomavirus shedding in the stool of healthy adults.Journal of clinical microbiology · 2009Article
- Presence and expression of JCV early gene large T Antigen in the brains of immunocompromised and immunocompetent individuals.Journal of medical virology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBK virus (BKV), JC virus (JCV) and simian virus 40 (SV40) are nonenveloped DNA viruses, members of the family Polyomaviridae. BK and JC viruses establish persistent infections in humans, and evidence suggests that SV40 can infect humans, as well. Whether persistence occurs in the lymphoid system is unknown.
methodsParaffin-embedded tonsils from 220 immunocompetent children (mean age 9.3 years) were examined by polymerase chain reaction (PCR) to detect viral DNA of BKV, JCV, SV40, and Epstein-Barr virus (EBV).
resultsPolyomavirus-specific DNA sequences were detected in 8.3% (29/351) of specimens collected from 220 children. Twenty-one (9.5%) children had polyomavirus DNA present in at least one tonsil, with sequences identified as SV40 (n=20) and BKV (n=1). Polyomavirus JCV was not detected. Among patients positive for SV40, 8 of 14 (57%) contained viral DNA in both available tonsils. EBV DNA was detected in 99 (28.2%) samples from 67 (30.5%) patients. Eleven samples (3.1%) from 8 (3.6%) children were positive for both polyomavirus and EBV. SV40-positive children were significantly older than the SV40-negative subjects (P<0.001). T-antigen expression was detected in an SV40 DNA-positive tonsil by immunohistochemistry.
conclusionsThese results suggest that SV40 can infect tonsils, that lymphoid tissue may represent a site for polyomavirus persistence, and that immunohistochemistry is not a useful detection assay when there are very few virus-infected cells in a tissue.
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