ArticleAlcohol (Fayetteville, N.Y.)2008
Alcohol consumption and cerebral blood flow among older adults.
Article in Alcohol (Fayetteville, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Variability of physiological brain perfusion in healthy subjects - A systematic review of modifiers. Considerations for multi-center ASL studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Guideline
- Imputation models and error analysis for phase contrast MR cerebral blood flow measurements.Frontiers in physiology · 2023Article
- Cerebral Blood Flow in the Salience Network of Individuals with Alcohol Use Disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Article
- Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span.Scientific reports · 2021Article
- Changes in Hemodynamic Response Function Resulting From Chronic Alcohol Consumption.Alcoholism, clinical and experimental research · 2020Article
- Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health.Psychological medicine · 2020Article
- Temporal Requirement for the Protective Effect of Dietary Cholesterol against Alcohol-Induced Vasoconstriction.Journal of drug and alcohol research · 2020Article
- Altered Regional Cerebral Blood Flow Associated with Mood and Sleep in Shift Workers: Cerebral Perfusion Magnetic Resonance Imaging Study.Journal of clinical neurology (Seoul, Korea) · 2019Article
- Applications ofChinese herbal medicines · 2019Article
- Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.Scientific reports · 2018Article
- Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers.Molecular psychiatry · 2017Article
- Neuroimaging in Alcohol and Drug Dependence.Current behavioral neuroscience reports · 2014Article
- Article
- Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease.Neurochemical research · 2012Review
- Frequent alcohol drinking is associated with lower prevalence of self-reported common cold: a retrospective study.BMC public health · 2012Article
- Article
- The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction.FEBS letters · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
A substantial epidemiological literature now supports the existence of a J or U-shaped association between alcohol consumption and a broad range cardiovascular health outcomes including stroke. Although it is well documented that alcoholics exhibit both global and regional cerebral hypoperfusion in the sober state, little is known regarding the effects of a broader range of alcohol consumption on cerebral blood flow (CBF). The present study employed positron emission tomography with H(2)(15)O to assess quantitative global and regional CBF in 86 participants (51 men and 35 women; mean age 60.1) as a function of self-reported weekly alcohol consumption (none, <1, 1 to <7, 7 to <15, and >15 drinks per week). Analyses controlling for age, gender, and vascular health (carotid intima-media thickness) revealed that, relative to the weighted population mean, global CBF was greater in the lightest alcohol consumption group (<1 per week) and lower in the heaviest (>15 per week). Effects did not vary across regions of interest. This report is the first to describe an inverted J-shaped relationship between alcohol consumption and CBF in the absence of stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.