ReviewThe Journal of allergy and clinical immunology2008
The role of protein digestibility and antacids on food allergy outcomes.
Review in The Journal of allergy and clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 265 citations in OpenAlex.
- Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence.Clinical reviews in allergy & immunology · 2023Pooled it
- Nutrigenomics-Associated Impacts of Nutrients on Genes and Enzymes With Special Consideration of Aromatase.Frontiers in nutrition · 2020Pooled it
- The safety and efficacy of sublingual and oral immunotherapy for milk allergy.The Journal of allergy and clinical immunology · 2012Trial
- Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants.The Journal of allergy and clinical immunology · 2010Trial
- Age-dependent plant protein digestibility and implications for epitope generation and hormonal secretion.Current research in food science · 2026Article
- Food allergies in older people: Protocol for a systematic review and meta-analysis.Nutrition and health · 2025Article
- Immune Reactivity to Raw and Processed Foods and Their Possible Contributions to Autoimmunity.Foods (Basel, Switzerland) · 2025Review
- Exploring the potential link between vegetable oil supplementation and adverse food reactions in dogs: a preliminary study.BMC veterinary research · 2025Article
- Food allergies in older people: An emerging health problem.The World Allergy Organization journal · 2024Review
- Optimization of nutritional and sensory properties of fermented oat-based composite beverage.Heliyon · 2022Article
- Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?Clinical reviews in allergy & immunology · 2022Review
- Investigation on the Anaphylaxis and Anti-Digestive Stable Peptides Identification of Ultrasound-Treated α-Lactalbumin during In-Vitro Gastroduodenal Digestion.Foods (Basel, Switzerland) · 2021Article
- Article
- IgE-Reactivity Pattern of Tomato Seed and Peel Nonspecific Lipid-Transfer Proteins afterJournal of agricultural and food chemistry · 2021Article
- Article
- Diet Diversity Through the Life-Course as an Opportunity Toward Food Allergy Prevention.Frontiers in allergy · 2021Article
- Erroneous Belief that Digestive Stability Predicts Allergenicity May Lead to Greater Risk for Novel Food Proteins.Frontiers in bioengineering and biotechnology · 2021Article
- Risk of Prevalent Asthma among Children Affected by Inflammatory Bowel Disease: A Population-Based Birth Cohort Study.International journal of environmental research and public health · 2020Article
- Food Allergy from Infancy Through Adulthood.The journal of allergy and clinical immunology. In practice · 2020Review
- Evidence runs contrary to digestive stability predicting protein allergenicity.Transgenic research · 2020Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Digestion assays with simulated gastric fluid have been introduced for characterization of food proteins to imitate the effect of stomach proteolysis on dietary compounds in vitro. By using these tests, dietary proteins can be categorized as digestion-resistant class 1 (true allergens triggering direct oral sensitization) or as labile class 2 allergens (nonsensitizing elicitors). Thus the results of these digestion assays mirror situations of intact gastric proteolysis. Alterations in the gastric milieu are frequently experienced during a lifetime either physiologically in the very young and the elderly or as a result of gastrointestinal pathologies. Additionally, acid-suppression medications are frequently used for treatment of dyspeptic disorders. By increasing the gastric pH, they interfere substantially with the digestive function of the stomach, leading to persistence of labile food protein during gastric transit. Indeed, both murine and human studies reveal that antiulcer medication increases the risk of food allergy induction. Gastric digestion substantially decreases the potential of food proteins to bind IgE, which increases the threshold dose of allergens required to elicit symptoms in patients with food allergy. Thus antiulcer agents impeding gastric protein digestion have a major effect on the sensitization and effector phase of food allergy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.