ArticleGenomics2009
Estimation and testing of gene-environment interactions in family-based association studies.
Article in Genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Case-Parent Trio Studies in Cleft Lip and Palate.Global medical genetics · 2020Review
- Observational
- Disease and Polygenic Architecture: Avoid Trio Design and Appropriately Account for Unscreened Control Subjects for Common Disease.American journal of human genetics · 2016Article
- Article
- Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.Human genetics · 2013Article
- Efficient simulation of epistatic interactions in case-parent trios.Human heredity · 2013Article
- Challenges and opportunities in genome-wide environmental interaction (GWEI) studies.Human genetics · 2012Review
- Allowing for sex differences increases power in a GWAS of multiplex Autism families.Molecular psychiatry · 2012Article
- Detection of intergenerational genetic effects with application to HLA-B matching as a risk factor for schizophrenia.Human heredity · 2011Article
- Testing gene-gene interactions in the case-parents design.Human heredity · 2011Article
- Discovering joint associations between disease and gene pairs with a novel similarity test.BMC genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Gene-environment interactions are of interest in genetic association studies for several reasons. First, the power to detect genetic effects may be substantially decreased if those effects differ according to environmental exposure and if no account is taken of this interaction with environmental exposure in the analysis. Second, such interactions may indicate a phenomenon of genuine biological interest (whereby a particular genetic effect operates only in the presence of an environmental trigger, or vice versa), understanding of which can lead us to a greater understanding of possible mechanisms and pathways in disease progression. Here I discuss the testing and estimation of gene-environment interactions via the case/pseudocontrol and related approaches. As originally proposed, the case/pseudocontrol approach applies to case/parents trios with no missing genotype data. I discuss some recent extensions that allow larger pedigree structures with some missing genotype data and present computer simulations to compare the performance of several competing approaches.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.