ReviewMolecular and cellular endocrinology2008
Membrane-initiated estrogen signaling in hypothalamic neurons.
Review in Molecular and cellular endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 100 citations in OpenAlex.
- Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways.Frontiers in molecular neuroscience · 2025Article
- Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.Nature communications · 2024Article
- Functional Aspects of Hypothalamic Asymmetry.Brain sciences · 2020Review
- Sex Differences and the Role of Estradiol in Mesolimbic Reward Circuits and Vulnerability to Cocaine and Opiate Addiction.Frontiers in behavioral neuroscience · 2020Review
- Eating as a motivated behavior: modulatory effect of high fat diets on energy homeostasis, reward processing and neuroinflammation.Integrative zoology · 2018Review
- Chemical control over membrane-initiated steroid signaling with a DNA nanocapsule.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons.Hormones and behavior · 2018Review
- Rapid effects of estradiol on aggression depend on genotype in a species with an estrogen receptor polymorphism.Hormones and behavior · 2018Article
- Gq Protein-Coupled Membrane-Initiated Estrogen Signaling Rapidly Excites Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus in Female Mice.Endocrinology · 2016Article
- Divergent Regulation of ER and Kiss Genes by 17β-Estradiol in Hypothalamic ARC Versus AVPV Models.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior.Frontiers in endocrinology · 2015Review
- Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats.PloS one · 2015Article
- Rapid effects of 17β-estradiol on male copulatory behaviors are not elicited by the novel membrane active estrogenic compound STX.Behavioral neuroscience · 2013Article
- Neuroprotective action of acute estrogens: animal models of brain ischemia and clinical implications.Steroids · 2013Review
- Neurosteroids, trigger of the LH surge.The Journal of steroid biochemistry and molecular biology · 2012Article
- Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.The journal of pain · 2012Article
- Estrogen receptor-beta and breast cancer: translating biology into clinical practice.Steroids · 2012Review
- Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.Brain research · 2012Article
- Membrane estrogen receptor regulation of hypothalamic function.Neuroendocrinology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is well known that many of the actions of 17beta-estradiol (E2) in the central nervous system are mediated via intracellular receptor/transcription factors that interact with steroid response elements on target genes. However, there is compelling evidence for membrane steroid receptors for estrogen in hypothalamic and other brain neurons. But it is not well understood how estrogen signals via membrane receptors, and how these signals impact not only membrane excitability but also gene transcription in neurons. Indeed, it has been known for sometime that E2 can rapidly alter neuronal activity within seconds, indicating that some cellular effects can occur via membrane delimited events. In addition, E2 can affect second messenger systems including calcium mobilization and a plethora of kinases to alter cell signaling. Therefore, this review will consider our current knowledge of rapid membrane-initiated and intracellular signaling by E2 in the hypothalamus, the nature of receptors involved and how they contribute to homeostatic functions.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.