ArticleMicrobes and infection2008
Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice.
Article in Microbes and infection, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Validation of Multiplex PCR and Serology DetectingMicroorganisms · 2023Article
- Comparative genomics analysis to differentiate metabolic and virulence gene potential in gastric versus enterohepatic Helicobacter species.BMC genomics · 2018Article
- Article
- Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice.Immunology · 2011Article
- Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer.Mucosal immunology · 2011Review
- Hemorrhage-induced intestinal damage is complement-independent in Helicobacter hepaticus-infected mice.Shock (Augusta, Ga.) · 2010Article
- The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models.Nature reviews. Microbiology · 2010Review
- A pathobiont of the microbiota balances host colonization and intestinal inflammation.Cell host & microbe · 2010Article
- Genome sequence of the emerging pathogen Helicobacter canadensis.Journal of bacteriology · 2009Article
- A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells.PloS one · 2009Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Helicobacter hepaticus strain 3B1 (H. hepaticus) contains a genomic island of approximately 71 kb, HHGI1, with some of the common features shared among known bacterial pathogenicity islands. In this study, we characterized the pathogenic potential of HHGI1 by infecting B6.129-IL10 tm1Cgn (IL10-/-) mice with an isogenic mutant (namely HhPAId1) lacking 19 predicted genes within HHGI1. In contrast to H. hepaticus (P<0.001), HhPAId1 did not cause typhlocolitis and hyperplasia in IL10-/- mice. Colonization levels of HhPAId1 were significantly higher in the cecum (P<0.007) and similar in the colon (P=0.27) when compared to H. hepaticus by 13 or 16 weeks post inoculation (WPI). The magnitude of the Th1-associated IgG2c response against HhPAId1 was less than that against H. hepaticus (P<0.004). There was no significant difference in Th2-associated IgG1 responses against these two strains. Cecal and colonic mRNA levels of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-17a in the HhPAId1-infected mice were significantly lower than those in the H. hepaticus-infected mice (P<0.05) at 13 WPI. These results demonstrate that genes in the HHGI1 contribute to the pathogenicity of H. hepaticus, at least in part via up-regulation of proinflammatory mediators IFN-gamma, TNF-alpha and IL-17a.
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