ArticleImmunity2008
pH-dependent interdomain tethers of CD1b regulate its antigen capture.
Article in Immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Nonclassical MHC-I Molecules: Emerging Therapeutic Targets in Next-Generation Immunotherapy.MedComm · 2026Review
- Article
- Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules.Science advances · 2020Article
- Group 1 CD1-restricted T cells contribute to control of systemic Staphylococcus aureus infection.PLoS pathogens · 2020Article
- A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The versatility of the CD1 lipid antigen presentation pathway.Immunology · 2018Review
- Molecular recognition of microbial lipid-based antigens by T cells.Cellular and molecular life sciences : CMLS · 2018Review
- A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.Science immunology · 2017Article
- CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.European journal of immunology · 2017Article
- Four pathways of CD1 antigen presentation to T cells.Current opinion in immunology · 2017Review
- Donor-unrestricted T cells in the human CD1 system.Immunogenetics · 2016Review
- CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity.Journal of immunology research · 2016Review
- Lipid and small-molecule display by CD1 and MR1.Nature reviews. Immunology · 2015Review
- Activation of human T cells by CD1 and self-lipids.Immunological reviews · 2015Review
- Regulation of Lipid Specific and Vitamin Specific Non-MHC Restricted T Cells by Antigen Presenting Cells and Their Therapeutic Potentials.Frontiers in immunology · 2015Review
- Role of Group 1 CD1-Restricted T Cells in Infectious Disease.Frontiers in immunology · 2015Review
- The CD1 size problem: lipid antigens, ligands, and scaffolds.Cellular and molecular life sciences : CMLS · 2014Review
- Lipid antigens in immunity.Biological chemistry · 2014Review
- Dynamics of the antigen-binding grooves in CD1 proteins: reversible hydrophobic collapse in the lipid-free state.The Journal of biological chemistry · 2013Article
- Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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12 authors.
Funding
Abstract
As CD1 proteins recycle between the cell surface and endosomes, they show altered receptiveness to lipid antigen loading. We hypothesized that changes in proton concentration encountered within distinct endosomal compartments influence the charge state of residues near the entrance to the CD1 groove and thereby control antigen loading. Molecular dynamic models identified flexible areas of the CD1b heavy chain in the superior and lateral walls of the A' pocket. In these same areas, residues that carry charge in a pH-dependent manner (D60, E62) were found to tether the rigid alpha1 helix to flexible areas of the alpha2 helix and the 50-60 loop. After disruption of these tethers with acid pH or mutation, we observed increased association and dissociation of lipids with CD1b and preferential presentation of antigens with bulky lipid tails. We propose that ionic tethers act as molecular switches that respond to pH fluxes during endosomal recycling and regulate the conformation of the CD1 heavy chain to control the size and rate of antigens captured.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.