Evidence map›Paper›PMID 18538409›Full record

ArticleOphthalmology2008

Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of Atherosclerosis.

Ronald Klein, Michael D Knudtson, Barbara E K Klein, Tien Y Wong, Mary Frances Cotch, Kiang Liu, Ching Y Cheng, Gregory L Burke, Mohammed F Saad, David R Jacobs and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00041444 (Multi-Ethnic Study of Atherosclerosis-Eye Study), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
7.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00041444 completednot on this map

Multi-Ethnic Study of Atherosclerosis-Eye Study

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2002 to 2006Enrolled6,176ConditionsAtherosclerosis, Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Dysregulated DNA Methylation inInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726-2397, USA. kleinr@epi.ophth.wisc.edu
Michael D Knudtson
Barbara E K Klein
Tien Y Wong
Mary Frances Cotch
Kiang Liu
Ching Y Cheng
Gregory L Burke
Mohammed F Saad
David R Jacobs
A Richey Sharrett
National Institutes of Health · USJohns Hopkins University · USNational University of Singapore · SGNorthwestern University · USStony Brook Medicine · USUniversity of Oslo · NOWake Forest University · US

Funding

Multi-ethnic Study Of Atherosclerosis - Vision ComponentZIAEY000403 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2009 to 2020
$1.8M
Multi-Ethnic Study of Atherosclerosis-Eye StudyR01HL069979 · NHLBI · UNIVERSITY OF WISCONSIN MADISON · PI KLEIN, RONALD · 2002 to 2005
$1.7M
Genetic Epidemiology of Complex TraitsZ01HG200327 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2005 to 2008
$1.3M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
Enhancing immune reconstitution after implantation of postnatal allogeneic thymusR21HL095165 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CROOKS, GAY M · 2008 to 2009
$440k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
Adjunctive Use of Apyrase to Fibrinolytic TherapyR43HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2009 to 2009
$226k
Multi-ethnic Study Of Atherosclerosis - Vision ComponentZ01EY000403 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2002 to 2008
$150k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READINGN01HC095169 · HC · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI DETRANO, ROBERT · 1999 to 2001
$124k
Intramural NIH HHS Z01 EY000403Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA EY000403NHLBI NIH HHS HL69979-03NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL069979
6 · The paper itself

Abstract

objectiveTo describe the relationship of systemic inflammatory disease, complement factor H (CFH) Y402H (1277T-->C) genotype status and age-related macular degeneration (AMD) prevalence in a multiethnic population of whites, blacks, Hispanics, and Chinese.

designPopulation-based, cross-sectional study.

participantsWe included 5887 persons aged 45 to 84 years with gradable AMD.

methodsDigital fundus photographs were used to measure AMD. Two years earlier, biomarkers of inflammation were measured and history of inflammatory disease and use of antiinflammatory agents obtained.

main outcome measurePrevalence of AMD.

resultsWhile controlling for age, gender, race/ethnicity, and study site, there were no associations between systemic inflammatory factors and AMD severity. Higher levels of high-sensitivity C-reactive protein (odds ratio [OR] per standard deviation [SD] increase in natural log [ln] units, 2.34; 95% confidence interval [CI], 1.33-4.13) and interleukin-6 (OR per SD in ln, 2.06; 95% CI, 1.21-3.49) were associated with geographic atrophy but not other AMD end points. History of periodontal disease (OR, 1.68; 95% CI, 1.14-2.47) was related to increased retinal pigment. A history of arthritis was associated with soft distinct drusen (OR, 1.24; 95% CI, 1.06-1.46). A history of oral steroid use was related to large drusen (OR, 2.13; 95% CI, 1.14-3.97) and soft distinct drusen (OR, 1.76; 95% CI, 1.00-3.10) and history of cyclooxygenase 2 inhibitor use were associated with large drusen (OR, 1.50; 95% CI, 1.10-2.04), soft indistinct drusen (OR, 1.84; 95% CI, 1.09-3.10), and large drusen area (OR, 1.66; 95% CI, 1.02-2.71). Whites, blacks, and Hispanics with CFH Y402H CC variant genotype had the highest frequency of early AMD compared with those with wild TT genotype. The frequency of CFH did explain some of the difference in AMD prevalence between Chinese and Hispanics compared with whites, but did not explain the difference in prevalence between whites and blacks.

conclusionsThis study confirmed associations of the Y402H CFH gene variant with AMD in nonwhite populations, but neither explained the lack of association between inflammatory factors and AMD in the cohort nor the basis for the observed differences in AMD prevalence across ethnic groups.

Indexed as

EthnicityPolymorphism, Single NucleotideAgedAged, 80 and overAnti-Inflammatory AgentsAtherosclerosisBiomarkersComplement Factor HC-Reactive ProteinCross-Sectional StudiesFemaleGenotypeHumansInflammationInterleukin-6Macular DegenerationAnti-Inflammatory AgentsBiomarkersCFH protein, humanComplement Factor HC-Reactive ProteinIL6 protein, humanInterleukin-6

Identifiers

PMID18538409
PMCPMC2936447
OpenAlexW1492973782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.