Antenatal indomethacin is more likely associated with spontaneous intestinal perforation rather than NEC.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

7 citing papers in PubMed.

1. The association between antenatal indomethacin exposure and persistent pulmonary hypertension of the newborn in extremely preterm infants.Scientific reports · 2025
   Article
2. Association of Intrapartum Drugs with Spontaneous Intestinal Perforation: A Single-Center Retrospective Review.American journal of perinatology · 2024
   Review
3. Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22-24 weeks' gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2024
   Observational
4. Spontaneous intestinal perforation (SIP) will soon become the most common form of surgical bowel disease in the extremely low birth weight (ELBW) infant.Journal of perinatology : official journal of the California Perinatal Association · 2022
   Review
5. Effect of prophylactic indomethacin administration and early feeding on spontaneous intestinal perforation in extremely low-birth-weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2017
   Article
6. Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age.Archives of disease in childhood. Fetal and neonatal edition · 2013
   Article
7. Evidence-based use of indomethacin and ibuprofen in the neonatal intensive care unit.Clinics in perinatology · 2012
   Review

Corrections and comments

• Comment on
  Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes.2007

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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