ArticleBMC microbiology2008
Genetic characterization of clinical and agri-food isolates of multi drug resistant Salmonella enterica serovar Heidelberg from Canada.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Integrated surveillance systems for antibiotic resistance in a One Health context: a scoping review.BMC public health · 2024Article
- Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-AssociatedVeterinary sciences · 2022Review
- Clustered Regularly Interspaced Short Palindromic Repeats Genotyping of Multidrug-ResistantFrontiers in microbiology · 2022Article
- Food-to-Humans Bacterial Transmission.Microbiology spectrum · 2020Review
- Non-typhoidalPathogens (Basel, Switzerland) · 2019Review
- Genomic Characterization of Extended-Spectrum Cephalosporin-ResistantFrontiers in microbiology · 2018Article
- Genome divergence and increased virulence of outbreak associatedGut pathogens · 2018Article
- Extended-Spectrum Cephalosporin-Resistant Salmonella enterica serovar Heidelberg Strains, the Netherlands(1).Emerging infectious diseases · 2016Article
- Identification and characterization of class 1 integrons among atypical enteropathogenic Escherichia coli isolated from children under 5 years of age.Iranian journal of microbiology · 2014Article
- Antimicrobial resistance genes in multidrug-resistant Salmonella enterica isolated from animals, retail meats, and humans in the United States and Canada.Microbial drug resistance (Larchmont, N.Y.) · 2013Article
- Effects of the Campylobacter jejuni CJIE1 prophage homologs on adherence and invasion in culture, patient symptoms, and source of infection.BMC microbiology · 2012Article
- Characterization of blaCMY-2 plasmids in Salmonella and Escherichia coli isolates from food animals in Canada.Applied and environmental microbiology · 2012Article
- Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.Antimicrobial agents and chemotherapy · 2010Article
- Resistance plasmid families in Enterobacteriaceae.Antimicrobial agents and chemotherapy · 2009Review
- Occurrence of spvA virulence gene and clinical significance for multidrug-resistant Salmonella strains.Journal of clinical microbiology · 2009Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSalmonella enterica serovar Heidelberg ranks amongst the most prevalent causes of human salmonellosis in Canada and an increase in resistance to extended spectrum cephalosporins (ESC) has been observed by the Canadian Integrated Program for Antimicrobial Resistance Surveillance. This study examined the genetic relationship between S. Heidelberg isolates from livestock, abattoir, retail meat, and clinical human specimens to determine whether there was a link between the emergence of MDR S. Heidelberg in chicken agri-food sources and the simultaneous increase of MDR S. Heidelberg in human clinical samples.
resultsChromosomal genetic homogeneity was observed by pulsed-field gel electrophoresis (PFGE), DNA sequence-based typing (SBT) and DNA microarray-based comparative genomic hybridization (CGH). Sixty one percent of isolates were indistinguishable by PFGE conducted using XbaI and BlnI restriction enzymes. An additional 15% of isolates had PFGE patterns that were closely related to the main cluster. SBT did not identify DNA polymorphisms and CGH revealed only genetic differences between the reference S. Typhimurium strain and S. Heidelberg isolates. Genetic variation observed by CGH between S. Heidelberg isolates could be attributed to experimental variation. Alternatively, plasmid content was responsible for differences in antimicrobial susceptibility, and restriction fragment length polymorphism (RFLP) analyses followed by replicon typing identified two divergent plasmid types responsible for ESC resistance.
conclusionDue to the overall limited genetic diversity among the isolates, it was not possible to identify variable traits that would be suitable for source tracking between human and agri-food isolates of S. Heidelberg in Canada.
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