ReviewBritish journal of clinical pharmacology2008
Pharmacokinetics and therapeutic drug monitoring of antiretrovirals in pregnant women.
Review in British journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review.PLoS medicine · 2016Pooled it
- Incident pregnancy and time to death or AIDS among HIV-positive women receiving antiretroviral therapy.PloS one · 2013Trial
- Trial
- Longitudinal analysis of viral suppression before, during, and after pregnancy among women on antiretroviral therapy in Uganda: six-year real-world experience.HIV research & clinical practice · 2026Article
- Pharmacokinetic Adaptations in Pregnancy: Implications for Optimizing Antiretroviral Therapy in HIV-Positive Women.Pharmaceutics · 2025Review
- Virological Outcomes Among Pregnant Women Receiving Antiretroviral Treatment in the Amhara Region, North West Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2023Article
- Effect of Pregnancy on Unbound Raltegravir Concentrations in the ANRS 160 RalFe Trial.Antimicrobial agents and chemotherapy · 2020Article
- Perinatal outcomes of twenty-five human immunodeficiency virus-infected pregnant women: Hacettepe University experienceJournal of the Turkish German Gynecological Association · 2020Article
- Article
- Article
- Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes?Drug metabolism and disposition: the biological fate of chemicals · 2013Article
- Prevalent pregnancy, biological sex, and virologic response to antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Adherence with drug therapy in pregnancy.Obstetrics and gynecology international · 2012Article
- Asking the right questions: developing evidence-based strategies for treating HIV in women and children.BMC public health · 2011Article
- Article
- Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life.The open AIDS journal · 2010Article
- Factors associated with HIV RNA levels in pregnant women on non-suppressive highly active antiretroviral therapy at conception.Antiviral therapy · 2010Article
- Protease inhibitor levels in hair strongly predict virologic response to treatment.AIDS (London, England) · 2009Article
- Chronic disease: when in doubt, consider accrual into a randomized controlled trial (RCT).British journal of clinical pharmacology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly active antiretroviral therapy is recommended for HIV-infected pregnant women to prevent mother-to-child transmission. The specific physiological background induced by pregnancy leads to significant changes in maternal pharmacokinetics, suggesting potential variability in plasma concentrations of antiretrovirals during gestation. Therapeutic drug monitoring (TDM) of protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) is recommended in certain situations, including pregnancy, but its systematic use in HIV-infected pregnant women remains controversial. This review provides an update of the pharmacokinetic data available for PIs and NNRTIs in pregnant women and highlights the clinical interest of systematic TDM of certain antiretroviral drugs during pregnancy, including nevirapine, nelfinavir, saquinavir, indinavir and lopinavir.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.