ReviewCNS & neurological disorders drug targets2008
GABAA receptors, anesthetics and anticonvulsants in brain development.
Review in CNS & neurological disorders drug targets, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- Assessment of Sedative Activity of Lonicerin: In Vivo Approach With Pharmacokinetics and Molecular Docking.Brain and behavior · 2025Article
- Ligand-gated ion channels as potential biomarkers for ADT-mediated cognitive decline in prostate cancer patients.Molecular carcinogenesis · 2024Article
- Efficacy and safety of ketamine for neonatal refractory status epilepticus: case report and systematic review.Frontiers in pediatrics · 2023Review
- Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance.Frontiers in cell and developmental biology · 2022Review
- GABAJournal, genetic engineering & biotechnology · 2021Review
- GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell.Cell death discovery · 2019Article
- Effects of gaboxadol on the expression of cocaine sensitization in rats.Experimental and clinical psychopharmacology · 2016Article
- Tranexamic acid-associated seizures: Causes and treatment.Annals of neurology · 2016Review
- GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies.Pharmacology & therapeutics · 2014Review
- Time-dependent modulation of GABA(A)-ergic synaptic transmission by allopregnanolone in locus coeruleus neurons of Mecp2-null mice.American journal of physiology. Cell physiology · 2013Article
- Anxiolytic effects of the GABA(A) receptor partial agonist, L-838,417: impact of age, test context familiarity, and stress.Pharmacology, biochemistry, and behavior · 2013Article
- AMPA and GABA(A/B) receptor subunit expression in the cortex of adult squirrel monkeys during peripheral nerve regeneration.Brain research · 2013Article
- GABAergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice.American journal of physiology. Cell physiology · 2013Article
- Effect of propofol in the immature rat brain on short- and long-term neurodevelopmental outcome.PloS one · 2013Article
- NKCC1 knockdown decreases neuron production through GABA(A)-regulated neural progenitor proliferation and delays dendrite development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Hippocampal extracellular signal-regulated kinase signaling has a role in passive avoidance memory retrieval induced by GABAA Receptor modulation in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.Current topics in microbiology and immunology · 2012Review
- Sedative and antiepileptic effects of Anthocephalus cadamba Roxb. in mice and rats.Indian journal of pharmacology · 2011Article
- Neurotransmitter signaling in postnatal neurogenesis: The first leg.Brain research reviews · 2010Review
- Early exposure to haloperidol or olanzapine induces long-term alterations of dendritic form.Synapse (New York, N.Y.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
GABA, acting via GABA(A) receptors, is well-accepted as the main inhibitory neurotransmitter of the mature brain, where it dampens neuronal excitability. The receptor's properties have been studied extensively, yielding important information about its structure, pharmacology, and regulation that are summarized in this review. Several GABAergic drugs have been commonly used as anesthetics, sedatives, and anticonvulsants for decades. However, findings that GABA has critical functions in brain development, in particular during the late embryonic and neonatal period, raise worthwhile questions regarding the side effects of GABAergic drugs that may lead to long-term cognitive deficits. Here, we will review some of these drugs in parallel with the control of CNS development that GABA exerts via activation of GABA(A) receptors. This review aims to provide a basic science and clinical perspective on the function of GABA and related pharmaceuticals acting at GABA(A) receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.