Evidence map›Paper›PMID 18536031›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2008

The circadian clock system in the mammalian retina.

Gianluca Tosini, Nikita Pozdeyev, Katsuhiko Sakamoto, P Michael Iuvone

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Associations between systemic melatonin and human myopia: A systematic review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023
    Pooled it
  2. Circadian IOP Rhythm in Rats Is Driven by Neural Signals From the Brain.Investigative ophthalmology & visual science · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. iScience · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Effect of Ambient Lighting on Intraocular Pressure Rhythms in Rats.Investigative ophthalmology & visual science · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. The Retinal Pigment Epithelium: Cells That Know the Beat!Advances in experimental medicine and biology · 2023
    Article
  19. Regulation of the rhythmic diversity of daily photoreceptor outer segment phagocytosis in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gianluca TosiniCircadian Rhythms and Sleep Disorders Program, Neuroscience Institute. Morehouse School of Medicine, Atlanta, GA, USA. gtosini@msm.edu
Nikita Pozdeyev
Katsuhiko Sakamoto
P Michael Iuvone

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H · 1986 to 2025
$15.3M
Neuromodulators and Circadian Clocks: Roles in Retinal Function and DysfunctionR01EY004864 · NEI · EMORY UNIVERSITY · PI IUVONE, P MICHAEL · 1985 to 2018
$7.0M
Photic and Circadian Regulation of Retinal MelatoninR01NS043459 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI TOSINI, GIANLUCA · 2003 to 2010
$2.3M
Neuromodulators and Signaling Cascades in RetinaR01EY014764 · NEI · EMORY UNIVERSITY · PI IUVONE, P MICHAEL · 2004 to 2007
$1.4M
Photic and circadian regulation of retinal melatoninR56NS043459 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI TOSINI, GIANLUCA · 2011 to 2011
$368k
NCATS NIH HHS UL1 TR000454NEI NIH HHS EY004864NEI NIH HHS EY 014764NEI NIH HHS P30 EY006360NEI NIH HHS R01 EY004864NEI NIH HHS R01 EY014764NINDS NIH HHS NS 43459NINDS NIH HHS R01 NS043459NINDS NIH HHS R56 NS043459
6 · The paper itself

Abstract

Daily rhythms are a ubiquitous feature of living systems. Generally, these rhythms are not just passive consequences of cyclic fluctuations in the environment, but instead originate within the organism. In mammals, including humans, the master pacemaker controlling 24-hour rhythms is localized in the suprachiasmatic nuclei of the hypothalamus. This circadian clock is responsible for the temporal organization of a wide variety of functions, ranging from sleep and food intake, to physiological measures such as body temperature, heart rate and hormone release. The retinal circadian clock was the first extra-SCN circadian oscillator to be discovered in mammals and several studies have now demonstrated that many of the physiological, cellular and molecular rhythms that are present within the retina are under the control of a retinal circadian clock, or more likely a network of hierarchically organized circadian clocks that are present within this tissue. BioEssays 30:624-633, 2008. (c) 2008 Wiley Periodicals, Inc.

Indexed as

MammalsRetinaAnimalsBiological ClocksCircadian RhythmCLOCK ProteinsFeedback, PhysiologicalHumansMelatoninPeriodicityPhotoreceptor CellsTrans-ActivatorsCLOCK protein, humanCLOCK ProteinsMelatoninTrans-Activators

Identifiers

PMID18536031
PMCPMC2505342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.