ArticleThe Journal of pathology2008
A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formation.
Article in The Journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis.Oncogene · 2023Article
- LIMK1: A promising prognostic and immune infiltration indicator in colorectal cancer.Oncology letters · 2022Article
- Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells.RNA biology · 2022Article
- MicroRNA-454-3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin-like growth factor 2 mRNA-binding protein 1.Oncology letters · 2020Article
- Mesenchymal stem cell-derived exosomes carrying microRNA-150 suppresses the proliferation and migration of osteosarcoma cells via targeting IGF2BP1.Translational cancer research · 2020Article
- IMP1 3' UTR shortening enhances metastatic burden in colorectal cancer.Carcinogenesis · 2019Article
- Article
- Post-transcriptional Regulation of Colorectal Cancer: A Focus on RNA-Binding Proteins.Frontiers in molecular biosciences · 2019Review
- The Molecular Basis of Metastatic Colorectal Cancer.Current colorectal cancer reports · 2018Article
- Mechanism of β-actin mRNA Recognition by ZBP1.Cell reports · 2017Article
- IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer.Genes & development · 2016Review
- IMP1, an mRNA binding protein that reduces the metastatic potential of breast cancer in a mouse model.Oncotarget · 2016Article
- MicroRNA-150 functions as a tumor suppressor in osteosarcoma by targeting IGF2BP1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.Molecular cancer research : MCR · 2015Article
- XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1.The Journal of biological chemistry · 2015Article
- miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma.Oncogene · 2015Article
- A Novel Role for VICKZ Proteins in Maintaining Epithelial Integrity during Embryogenesis.PloS one · 2015Article
- The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules.The Journal of cell biology · 2013Article
- IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts.Carcinogenesis · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
VICKZ proteins are a highly conserved family of RNA binding proteins, implicated in RNA regulatory processes such as intracellular RNA localization, RNA stability, and translational control. During embryogenesis, VICKZ proteins are required for neural crest migration and in adults, the proteins are overexpressed primarily in different cancers. We hypothesized that VICKZ proteins may play a role in cancer cell migration. In patients, VICKZ expression varies with tumour type, with over 60% of colon, lung, and ovarian tumours showing strong expression. In colorectal carcinomas (CRCs), expression is detected at early stages, and the frequency and intensity of staining increase with progression of the disease to lymph node metastases, of which 97% express the protein at high levels. Indeed, in stage II CRC, the level of VICKZ expression in the primary lesion correlates with the degree of lymph node metastasis. In culture, VICKZ proteins rapidly accumulate in processes at the leading edge of PMA-stimulated SW480 CRC cells, where they co-localize with beta-actin mRNA. Two distinct cocktails of shRNAs, each targeting all three VICKZ paralogues, cause a dramatic drop in lamellipodia and ruffle formation in stimulated cells. Thus, VICKZ proteins help to facilitate the dynamic cell surface morphology required for cell motility. We propose that these proteins play an important role in CRC metastasis by shuttling requisite RNAs to the lamellipodia of migrating cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.