ArticlePLoS genetics2008
Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Insight into the Role of Epigenetic Processes in Abiotic and Biotic Stress Response in Wheat and Barley.International journal of molecular sciences · 2020Review
- Loss of ISWI Function in Drosophila Nuclear Bodies Drives Cytoplasmic Redistribution of Drosophila TDP-43.International journal of molecular sciences · 2018Article
- A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1.G3 (Bethesda, Md.) · 2015Article
- Elements of the cellular metabolic structure.Frontiers in molecular biosciences · 2015Article
- Regulation of ISWI chromatin remodelling activity.Chromosoma · 2014Review
- The conserved PBAF nucleosome-remodeling complex mediates the response to stress in Caenorhabditis elegans.Molecular and cellular biology · 2014Article
- Article
- ISWI contributes to ArsI insulator function in development of the sea urchin.Development (Cambridge, England) · 2012Article
- Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain.Developmental cell · 2012Article
- Article
- Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI.The EMBO journal · 2011Article
- The ISWI chromatin remodeler organizes the hsrω ncRNA-containing omega speckle nuclear compartments.PLoS genetics · 2011Article
- Article
- Functional antagonism between histone H3K4 demethylases in vivo.Genes & development · 2011Article
- The roles of PARP1 in gene control and cell differentiation.Current opinion in genetics & development · 2010Review
- Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor.Molecular cancer · 2010Article
- The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors.Genetics · 2010Article
- Divergent human remodeling complexes remove nucleosomes from strong positioning sequences.Nucleic acids research · 2010Article
- Genome-wide analysis of interactions between ATP-dependent chromatin remodeling and histone modifications.BMC genomics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Nucleosome remodeling and covalent modifications of histones play fundamental roles in chromatin structure and function. However, much remains to be learned about how the action of ATP-dependent chromatin remodeling factors and histone-modifying enzymes is coordinated to modulate chromatin organization and transcription. The evolutionarily conserved ATP-dependent chromatin-remodeling factor ISWI plays essential roles in chromosome organization, DNA replication, and transcription regulation. To gain insight into regulation and mechanism of action of ISWI, we conducted an unbiased genetic screen to identify factors with which it interacts in vivo. We found that ISWI interacts with a network of factors that escaped detection in previous biochemical analyses, including the Sin3A gene. The Sin3A protein and the histone deacetylase Rpd3 are part of a conserved histone deacetylase complex involved in transcriptional repression. ISWI and the Sin3A/Rpd3 complex co-localize at specific chromosome domains. Loss of ISWI activity causes a reduction in the binding of the Sin3A/Rpd3 complex to chromatin. Biochemical analysis showed that the ISWI physically interacts with the histone deacetylase activity of the Sin3A/Rpd3 complex. Consistent with these findings, the acetylation of histone H4 is altered when ISWI activity is perturbed in vivo. These findings suggest that ISWI associates with the Sin3A/Rpd3 complex to support its function in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.