Evidence map›Paper›PMID 18535146›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2008

Tegument proteins of human cytomegalovirus.

Robert F Kalejta

Open access · bronzeAbstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 200 citations in OpenAlex.

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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Robert F KalejtaInstitute for Molecular Virology and McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, USA. rfkalejta@wisc.edu
University of Wisconsin–Madison · US

Funding

Role of Daxx degradation by pp71 during the Human Cytomegalovirus life cycleR01AI074984 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KALEJTA, ROBERT F · 2008 to 2018
$3.5M
Role and Cell Cycle Mechanisms of pp71 in HCMV InfectionR56AI064703 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KALEJTA, ROBERT F · 2007 to 2007
$294k
NIAID NIH HHS 1R56-AI64703-01A2NIAID NIH HHS R01 AI074984NIAID NIH HHS R56 AI064703
6 · The paper itself

Abstract

summaryHuman cytomegalovirus (HCMV) is a common, medically relevant human herpesvirus. The tegument layer of herpesvirus virions lies between the genome-containing capsids and the viral envelope. Proteins within the tegument layer of herpesviruses are released into the cell upon entry when the viral envelope fuses with the cell membrane. These proteins are fully formed and active and control viral entry, gene expression, and immune evasion. Most tegument proteins accumulate to high levels during later stages of infection, when they direct the assembly and egress of progeny virions. Thus, viral tegument proteins play critical roles at the very earliest and very last steps of the HCMV lytic replication cycle. This review summarizes HCMV tegument composition and structure as well as the known and speculated functions of viral tegument proteins. Important directions for future investigation and the challenges that lie ahead are identified and discussed.

Indexed as

CytomegalovirusCytomegalovirus InfectionsHumansViral Structural ProteinsVirionVirus ReplicationViral Structural Proteins

Identifiers

PMID18535146
PMCPMC2415745
OpenAlexW2097785895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.