ArticleEndocrinology2008
Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- CCN Proteins as Matricellular Regulators of Bone in Aging and Disease.Current osteoporosis reports · 2025Review
- Blocking CCN2 Reduces Established Bone Loss Induced by Prolonged Intense Loading by Increasing Osteoblast Activity in Rats.JBMR plus · 2023Article
- Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease.International journal of molecular sciences · 2021Review
- CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis.Journal of cell communication and signaling · 2021Review
- The BMP-2 mutant L51P: a BMP receptor IA binding-deficient inhibitor of noggin.Journal of bone and mineral metabolism · 2019Review
- Article
- Restoration of murine femoral segmental defect using CTGF-overexpressing MC3T3-E1 cells.American journal of translational research · 2016Article
- WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.The Journal of biological chemistry · 2015Article
- Article
- Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage.Bone · 2014Article
- Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling.Journal of cellular physiology · 2014Article
- E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-β in the bone microenvironment.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Conditional inactivation of noggin in the postnatal skeleton causes osteopenia.Endocrinology · 2012Article
- TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction.Endocrinology · 2012Article
- Gremlin1 is required for skeletal development and postnatal skeletal homeostasis.Journal of cellular physiology · 2012Article
- Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets.Nature reviews. Drug discovery · 2011Review
- CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Nephroblastoma overexpressed (Nov) induces gremlin in ST-2 stromal cell lines by post-transcriptional mechanisms.Journal of cellular biochemistry · 2011Article
- WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis.Critical reviews in eukaryotic gene expression · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Connective tissue growth factor (CTGF), a member of the CCN family of proteins, is expressed in skeletal cells, and the ctgf null mutation leads to neonatal lethality due to defects in skeletal development. To define the function of CTGF in the postnatal skeleton, we created transgenic mice overexpressing CTGF under the control of the human osteocalcin promoter. CTGF transgenic female and male mice exhibited a significant decrease in bone mineral density, compared with wild-type littermate controls. Bone histomorphometry revealed that CTGF overexpression caused decreased trabecular bone volume due to impaired osteoblastic activity because mineral apposition and bone formation rates were decreased. Osteoblast and osteoclast number and bone resorption were not altered. Calvarial osteoblasts and stromal cells from CTGF transgenics displayed decreased alkaline phosphatase and osteocalcin mRNA levels and reduced bone morphogenetic protein (BMP) signaling mothers against decapentaplegic, Wnt/beta-catenin, and IGF-I/Akt signaling. In conclusion, CTGF overexpression in vivo causes osteopenia, secondary to decreased bone formation, possibly by antagonizing BMP, Wnt, and IGF-I signaling and activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.