ArticleThe Journal of physiology2008
Assessing the physiological concentration and targets of nitric oxide in brain tissue.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.Bioactive materials · 2027Review
- The Role of Nitric Oxide in Cancer Treatment: Ally or Foe?Molecules (Basel, Switzerland) · 2025Review
- Nitric Oxide Sensing by a Blue Fluorescent Protein.Antioxidants (Basel, Switzerland) · 2022Article
- Hyperoxia evokes pericyte-mediated capillary constriction.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Inflammatory Response Mechanisms of the Dentine-Pulp Complex and the Periapical Tissues.International journal of molecular sciences · 2021Review
- Non-signalling energy use in the developing rat brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Energy and Potassium Ion Homeostasis during Gamma Oscillations.Frontiers in molecular neuroscience · 2016Review
- Article
- Endothelial nitric oxide: protector of a healthy mind.European heart journal · 2014Review
- Article
- Metabolic differentiation in the embryonic retina.Nature cell biology · 2012Article
- Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration.International journal of cell biology · 2012Article
- Picomolar nitric oxide signals from central neurons recorded using ultrasensitive detector cells.The Journal of biological chemistry · 2011Article
- Glial and neuronal control of brain blood flow.Nature · 2010Review
- Cellular in vivo imaging reveals coordinated regulation of pituitary microcirculation and GH cell network function.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Past, present and future therapeutics for cerebellar ataxias.Current neuropharmacology · 2010Article
- Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells.Nature nanotechnology · 2009Article
- What is the real physiological NO concentration in vivo?Nitric oxide : biology and chemistry · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Low nanomolar concentrations of nitric oxide activate guanylyl cyclase to produce cGMP, which has diverse physiological effects. Higher concentrations inhibit mitochondrial respiration at cytochrome c oxidase and this has been proposed to be important physiologically, increasing oxygen permeation into tissue (by reducing the oxygen use of cells near blood vessels), activating AMP kinase, and regulating the relationship between cerebral blood flow and oxygen use. It is unclear, however, whether nitric oxide can accumulate physiologically to concentrations at which inhibition of respiration occurs. In rat cerebellar slices, we activated nitric oxide production from each isoform of nitric oxide synthase. Only activation of inducible nitric oxide synthase, which is expressed pathologically, caused any significant inhibition of respiration. Modelling oxygen and nitric oxide concentrations predicted that, in vivo, physiological nitric oxide levels are too low to affect respiration. Even pathologically, the nitric oxide concentration may only rise to 2.5 nm, producing a 1.5% inhibition of respiration. Thus, under physiological conditions, nitric oxide signals do not inhibit respiration but are well-tuned to the dynamic range of guanylyl cyclase activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.