ArticleNucleic acids research2008
Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 76 citations in OpenAlex.
- Quadruplex-duplex junction in LTR-III: A molecular insight into the complexes with BMH-21, namitecan and doxorubicin.PloS one · 2024Article
- PhenQE8, a Novel Ligand of the Human Telomeric Quadruplex.International journal of molecular sciences · 2021Article
- Conformational polymorphism or structural invariance in DNA photoinduced lesions: implications for repair rates.Nucleic acids research · 2017Article
- Structure, Properties, and Biological Relevance of the DNA and RNA G-Quadruplexes: Overview 50 Years after Their Discovery.Biochemistry. Biokhimiia · 2016Article
- Molecular dynamics and principal components of potassium binding with human telomeric intra-molecular G-quadruplex.Protein & cell · 2015Article
- G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy.Chemical science · 2015Article
- Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity.Nucleic acids research · 2013Article
- G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold.Nucleic acids research · 2013Article
- Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection.Nucleic acids research · 2013Article
- Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis.Journal of the American Chemical Society · 2011Article
- Kinetically governed polymorphism of d(G₄T₄G₃) quadruplexes in K+ solutions.Nucleic acids research · 2011Article
- Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4.Journal of nucleic acids · 2011Article
- Intracellular traffic of oligodeoxynucleotides in and out of the nucleus: effect of exportins and DNA structure.Oligonucleotides · 2010Article
- "One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.Journal of nucleic acids · 2010Article
- Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescence.Biochemistry · 2010Article
- Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs.Nucleic acids research · 2009Article
- Duplex formation at the 5' end affects the quadruplex conformation of the human telomeric repeat overhang in sodium but not in potassium.Biochemistry · 2009Article
- Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.Nucleic acids research · 2009Article
- Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions.Nucleic acids research · 2009Article
- Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
G-quadruplex structures formed in the telomeric DNA are thought to play a role in the telomere function. Drugs that stabilize the G-quadruplexes were shown to have anticancer effects. The structures formed by the basic telomeric quadruplex-forming unit G(3)(TTAG(3))(3) were the subject of multiple studies. Here, we employ (125)I-radioprobing, a method based on analysis of the distribution of DNA breaks after decay of (125)I incorporated into one of the nucleotides, to determine the fold of the telomeric DNA in the presence of TMPyP4 and telomestatin, G-quadruplex-binding ligands and putative anticancer drugs. We show that d[G(3)(TTAG(3))(3)(125)I-CT] adopts basket conformation in the presence of NaCl and that addition of either of the drugs does not change this conformation of the quadruplex. In KCl, the d[G(3)(TTAG(3))(3)(125)I-CT] is most likely present as a mixture of two or more conformations, but addition of the drugs stabilize the basket conformation. We also show that d[G(3)(TTAG(3))(3)(125)I-CT] with a 5'-flanking sequence folds into (3+1) type 2 conformation in KCl, while in NaCl it adopts a novel (3+1) basket conformation with a diagonal central loop. The results demonstrate the structural flexibility of the human telomeric DNA; and show how cations, quadruplex-binding drugs and flanking sequences can affect the conformation of the telomeric quadruplex.
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