ArticleComparative biochemistry and physiology. Part B, Biochemistry & molecular biology2008
Silencing the genes for dopa decarboxylase or dopachrome conversion enzyme reduces melanization of foreign targets in Anopheles gambiae.
Article in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- 3,4-Dihydroxyphenylacetaldehyde synthase evolved an ordered structure to deliver oxygen to pyridoxal 5'-phosphate for cuticle assembly in the mosquito Aedes aegypti.Nature communications · 2025Article
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- The immune deficiency and c-Jun N-terminal kinase pathways drive the functional integration of the immune and circulatory systems of mosquitoes.Open biology · 2022Article
- A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals.Frontiers in molecular biosciences · 2018Review
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- Structural Basis of the Substrate Specificity and Enzyme Catalysis of aFrontiers in molecular biosciences · 2017Article
- Critical Analysis of the Melanogenic Pathway in Insects and Higher Animals.International journal of molecular sciences · 2016Review
- Overloading the immunity of the mosquito Anopheles gambiae with multiple immune challenges.Parasites & vectors · 2016Article
- Phenylalanine metabolism regulates reproduction and parasite melanization in the malaria mosquito.PloS one · 2014Article
- Article
- Article
- Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase.PloS one · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The production of melanin is a complex biochemical process in which several enzymes may play a role. Although phenoloxidase and serine proteases are clearly key components, the activity of other enzymes, including dopa decarboxylase and dopachrome conversion enzyme may also be required. We tested the effect of knockdown of gene expression for these two enzymes on melanization of abiotic targets in the mosquito, Anopheles gambiae. Knockdown of dopa decarboxylase and dopachrome conversion enzyme resulted in a significant reduction of melanization of Sephadex beads at 24 h after injection. Knockdown of a third enzyme, phenylalanine hydroxylase, which is involved in endogenous production of tyrosine, had no effect on bead melanization. Quantitative analysis of gene expression demonstrated significant upregulation of phenylalanine hydroxylase, but not the other two genes, following injection.
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Registered trials
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