Evidence map›Paper›PMID 18534554›Full record

Trial reportArchives of physical medicine and rehabilitation2008

The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease.

Beth E Fisher, Allan D Wu, George J Salem, Jooeun Song, Chien-Ho Janice Lin, Jeanine Yip, Steven Cen, James Gordon, Michael Jakowec, Giselle Petzinger

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of physical medicine and rehabilitation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02447146 (Effects of Resistance Training on Bradykinesia and Physical Function in Patients With Parkinson's Disease.), which is not on this map. Cited by 175 papers, 27 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 27 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02447146 nacompletednot on this mapstarted 2013, after this paper: background citation

Effects of Resistance Training on Bradykinesia and Physical Function in Patients With Parkinson's Disease.

TypeinterventionalSponsorUniversity of BrasiliaRan2013 to 2014Enrolled40ConditionsParkinson DiseaseArmsResistance Training, Lectures on the disease
3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 27 syntheses or guidelines pooled it, 472 citations in OpenAlex.

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  20. Current Perspectives on Aerobic Exercise in People with Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Pooled it

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Beth E FisherDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90089-9006, USA. bfisher@usc.edu
Allan D Wu
George J Salem
Jooeun Song
Chien-Ho Janice Lin
Jeanine Yip
Steven Cen
James Gordon
Michael Jakowec
Giselle Petzinger
University of Southern California · USUniversity of California, Los Angeles · US

Funding

Motor cortex function in unimanual goal-directed aimingK23NS045764 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WU, ALLAN D · 2004 to 2008
$877k
NINDS NIH HHS K23 NS045764NINDS NIH HHS K23-NS045764
6 · The paper itself

Abstract

objectivesTo obtain preliminary data on the effects of high-intensity exercise on functional performance in people with Parkinson's disease (PD) relative to exercise at low and no intensity and to determine whether improved performance is accompanied by alterations in corticomotor excitability as measured through transcranial magnetic stimulation (TMS).

designCohort (prospective), randomized controlled trial.

settingUniversity-based clinical and research facilities.

participantsThirty people with PD, within 3 years of diagnosis with Hoehn and Yahr stage 1 or 2.

interventionsSubjects were randomized to high-intensity exercise using body weight-supported treadmill training, low-intensity exercise, or a zero-intensity education group. Subjects in the 2 exercise groups completed 24 exercise sessions over 8 weeks. Subjects in the zero-intensity group completed 6 education classes over 8 weeks.

main outcome measuresUnified Parkinson's Disease Rating Scales (UPDRS), biomechanic analysis of self-selected and fast walking and sit-to-stand tasks; corticomotor excitability was assessed with cortical silent period (CSP) durations in response to single-pulse TMS.

resultsA small improvement in total and motor UPDRS was observed in all groups. High-intensity group subjects showed postexercise increases in gait speed, step and stride length, and hip and ankle joint excursion during self-selected and fast gait and improved weight distribution during sit-to-stand tasks. Improvements in gait and sit-to-stand measures were not consistently observed in low- and zero-intensity groups. The high-intensity group showed lengthening in CSP.

conclusionsThe findings suggest the dose-dependent benefits of exercise and that high-intensity exercise can normalize corticomotor excitability in early PD.

Indexed as

Exercise TherapyAgedFeasibility StudiesFemaleGait Disorders, NeurologicHumansMaleMiddle AgedMotor CortexNeuronal PlasticityParkinson DiseasePostural BalanceProspective StudiesTask Performance and AnalysisTranscranial Magnetic StimulationTreatment Outcome

Identifiers

PMID18534554
PMCPMC2989816
OpenAlexW2148747456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.